Analysis Tools
behavior/neurological
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IMPC - KMPC
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IMPC - KMPC
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Allele Symbol Allele Name Allele ID |
Hdac2+ wild type MGI:2436781 |
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| Summary |
5 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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IMPC - KMPC
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IMPC - KMPC
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 7 days following ischemic injury, mice exhibit a less significant decrease in ERG waveforms and reduced loss of retinal thickness with only a slight decrease in the inner plexiform layer and inner nuclear layer thickness compared with wild-type mice
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• 7 days following ischemic injury, mice exhibit a reduced loss of retinal thickness compared with wild-type mice
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• 7 days following ischemic injury, mice exhibit a less significant decrease in ERG waveforms compared with wild-type mice
• however, baseline readings are normal
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• 7 days following ischemic injury, mice exhibit a less significant decrease in ERG waveforms and reduced loss of retinal thickness with only a slight decrease in the inner plexiform layer and inner nuclear layer thickness compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in pIpC-treated mice
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• megakaryocytes from pIpC-treated mice exhibit aberrant nuclear morphology and mitotic figures and are frequently found intra-vascular or extravasating into bone marrow blood vessels and in the liver compared with control cells
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• in the bone marrow of pIpC-treated mice without increased apoptosis
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• 2-fold in pIpC-treated mice
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• 6-fold in pIpC-treated mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all mice die at an average of 15 weeks
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• in diseased mice
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• 5-fold reduction in cellularity in neonates
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• in diseased mice
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• in the percentage but not the absolute numbers
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• increase in CD4low/CD8high cells at 6 to 8 weeks
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• block at the double negative to double positive transition
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• 4-fold increase in the percent of immature single positive cells at 6 to 8 weeks
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• in 1 of 8 mice
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• in moribund mice
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• in moribund mice
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• in diseased mice
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• in moribund mice
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• in diseased mice
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• 5-fold reduction in cellularity in neonates
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• in diseased mice
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• in the percentage but not the absolute numbers
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• increase in CD4low/CD8high cells at 6 to 8 weeks
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• block at the double negative to double positive transition
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• 4-fold increase in the percent of immature single positive cells at 6 to 8 weeks
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• in diseased mice
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• 5-fold reduction in cellularity in neonates
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• double mutants show similar but more obvious hair and skin phenotypes than single Hdac1 conditional homozygotes
• characteristic hair types are replaced by abnormally pigmented, shorter, thinner hairs with misshaped and twisted medulla structures
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• mice show more severe supernumerary claw phenotypes than single Hdac1 conditional homozygotes
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• mice show more severe pigmentation in the claws than single Hdac1 conditional homozygotes
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• vibrissa hair fiber thickness and length are reduced
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• interfollicular epithelium is hyperpigmented
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• foot skin epithelium is hyperkeratotic
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• mice show more severe pigmentation of the footpads and feet than single Hdac1 conditional homozygotes
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• mice show more severe pigmentation of the footpads and feet than single Hdac1 conditional homozygotes
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• mice show more severe pigmentation of the footpads and feet than single Hdac1 conditional homozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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