All Phenotypes Flna<+> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Flna^tm1.2Caw/Flna⁺	involves: 129S4/SvJae * C57BL/6	MGI:3699952
ht2	Flna^Dilp2/Flna⁺	involves: BALB/cAnN * C3H/HeN	MGI:2686843
ht3	Flna^Dilp2/Flna⁺	involves: BALB/cAnN * C3H/HeN * C57BL/6	MGI:3688534

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:118252 )

• about 20% of females die in the initial 3-4 months of life with many anomalies

postnatal lethality, incomplete penetrance ( J:118252 )

• some females die after birth; only about 50% of expected female heterozygous mice are observed at weaning

preweaning lethality, incomplete penetrance ( J:118252 )

• some females die early; only ~50% of expected female heterozygous mice are observed at weaning

cardiovascular system

abnormal heart morphology ( J:118252 )

dilated heart ( J:118252 )

• some females that die at 3-4 months display heart dilation

hematopoietic system

increased leukocyte cell number ( J:118252 )

• leukocytosis seen in some dead females at 3-4 months

homeostasis/metabolism

abnormal thrombosis ( J:118252 )

• some females that die at 3-4 months have liver thrombi

edema ( J:118252 )

• some females that die at 3-4 months show lung edema

immune system

increased leukocyte cell number ( J:118252 )

• leukocytosis seen in some dead females at 3-4 months

liver/biliary system

hepatic necrosis ( J:118252 )

• seen in some dead females at 3-4 months

reproductive system

reduced female fertility ( J:118252 )

• heterozygous females are poor breeders

respiratory system

emphysema ( J:118252 )

• some females that die at 3-4 months display emphysema

Allelic Composition	Flna^Dilp2/Flna⁺
Genetic Background	involves: BALB/cAnN * C3H/HeN

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flna^Dilp2 mutation (2 available); any Flna mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye morphology ( J:75964 )

mydriasis ( J:75964 )

Allelic Composition	Flna^Dilp2/Flna⁺
Genetic Background	involves: BALB/cAnN * C3H/HeN * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flna^Dilp2 mutation (2 available); any Flna mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

double outlet right ventricle ( J:112274 )

• seen in 1 of 8 females

ventricular septal defect ( J:112274 )

• 2 of 8 females exhibit ventricular septal defects

craniofacial

abnormal palatal shelf fusion at midline ( J:112274 )

• in many females, the palatal shelves are elevated correctly, however they remain incompletely fused

skeleton

abnormal sternum morphology ( J:112274 )

• exhibit incomplete fusion of the sternum at E15.5, although with less severity than in males

• although fusion occurs by adulthood, the sternum appears compressed and misshapen and is thicker and shorter than in wild-type

abnormal xiphoid process morphology ( J:112274 )

• abnormal in adult females

vision/eye

irregularly shaped pupil ( J:112274 )

digestive/alimentary system

abnormal palatal shelf fusion at midline ( J:112274 )

• in many females, the palatal shelves are elevated correctly, however they remain incompletely fused

growth/size/body

abnormal palatal shelf fusion at midline ( J:112274 )

• in many females, the palatal shelves are elevated correctly, however they remain incompletely fused

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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