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Allele Symbol Allele Name Allele ID |
Bace1+ wild type MGI:2438263 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in newborn mice persisting through adulthood
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• in newborn mice persisting through adulthood
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are significantly impaired in Morris water maze tasks
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• high level of amyloid beta aggregates are found in brain at 12 months of age
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• in 12-month old brains, there is a 27% reduction in amyloid beta aggregates compared to transgenic mice that are wild-type for Bace1; there are no significant differences at 20 months
• in 12-month old brains, there is 37% reduction in percentage of brain volume occupied by amyloid beta deposits, but no difference at 20 months
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• high level of amyloid beta aggregates are found in brain at 12 months of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice with transgene expression induced by removal of doxycycline from the food 4-6 weeks postnatal exhibit decreased amyloid beta in the hippocampus
• mice exhibit normal synaptic plasticity and long term potentiation (LTP) is fully restored following a 6-week induction
• mice exhibit normal density of synaptophysin puncta in the stratum radiatum of the hippocampus, indicating restoration of synapse density, following a 6-week induction
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• brain weight is reduced in 6-week induced mice
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• reduction in the number of NeuN-positive cells in hippocampal area CA1 in 6-week induced mice
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• reactive astrogliosis is seen in the cortex and hippocampus in 6-week induced mice
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| N |
• 6-week induced mice show improved associate learning in contextual fear conditioning and are indistinguishable from controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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