Phenotypes associated with this allele

• Allele Symbol: Cops6⁺
• Allele Name: wild type
• Allele ID: MGI:2438359
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Cops6^Gt(RRI087)Byg/Cops6^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:5003352
cx2	Cops6^Gt(RRI087)Byg/Cops6^+ Trp53^tm1Glo/Trp53^+	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	MGI:5003356

Genotype
MGI:5003352

ht1

• Allelic Composition: Cops6^{Gt(RRI087)Byg}/Cops6⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increase in gamma-irradiation-induced apoptosis in Cops6^{Gt(RRI087)Byg}/Cops6⁺ thymus and developing central nervous system

mortality/aging

increased mortality induced by gamma-irradiation ( J:172038 )

cellular

increased sensitivity to induced cell death ( J:172038 )

• mouse embryonic fibroblasts exhibit increased sensitivity to doxorubicin-induced apoptosis compared with wild-type cells

increased cellular sensitivity to gamma-irradiation ( J:172038 )

• in mouse embryonic fibroblasts

increased thymocyte apoptosis ( J:172038 )

• gamma-irradiation-induced

neoplasm

decreased incidence of tumors by ionizing radiation induction ( J:172038 )

• mice exhibit a reduced incidence of gamma-irradiation-induced tumors compared with wild-type mice

immune system

increased thymocyte apoptosis ( J:172038 )

• gamma-irradiation-induced

hematopoietic system

increased thymocyte apoptosis ( J:172038 )

• gamma-irradiation-induced

homeostasis/metabolism

increased mortality induced by gamma-irradiation ( J:172038 )

endocrine/exocrine glands

increased thymocyte apoptosis ( J:172038 )

• gamma-irradiation-induced

Genotype
MGI:5003356

cx2

• Allelic Composition: Cops6^{Gt(RRI087)Byg}/Cops6⁺; Trp53^tm1Glo/Trp53⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

neoplasm

increased incidence of tumors by ionizing radiation induction ( J:172038 )

• mice exhibit a spectrum of gamma-irradiation-induced tumors intermediate to in Trp53^tm1Glo heterozygotes and Cops6^{Gt(RRI087)Byg} heterozygotes