All Phenotypes Asgr2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Asgr2⁺
wild type
MGI:2439079

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Asgr2^tm1Her/Asgr2⁺	involves: 129S7/SvEvBrd * C57BL/6	MGI:3511246

Allelic Composition	Asgr2^tm1Her/Asgr2⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Asgr2^tm1Her mutation (2 available); any Asgr2 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal homeostasis ( J:21380 )

• heterozygotes are overtly normal but express reduced levels of ASGR1 protein, and clear asialoorosomucoid with intermediate efficiency from their circulation relative to wild-type

• however, similar to wild-type mice, heterozygotes fail to clear non-desialylated (125)I-labeled orosomucoid

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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