All Phenotypes Agrp<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Agrp⁺
wild type
MGI:2439117

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Agrp^{tm2(HBEGF)Rpa}/Agrp⁺	involves: 129S4/SvJaeSor * C57BL/6	MGI:3776081
cn2	Agrp^{tm2(HBEGF)Rpa}/Agrp⁺ Grin1^tm2Stl/Grin1^tm2Stl	involves: 129S4/SvJae * 129S4/SvJaeSor	MGI:5427451
cn3	Agrp^{tm2(HBEGF)Rpa}/Agrp⁺ Tph2^tm1Mscl/Tph2^tm1Mscl	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr	MGI:5427450
cn4	Rock1^tm1.1Itl/Rock1^tm1.1Itl Agrp^tm1(cre)Lowl/Agrp⁺	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	MGI:5543678
cn5	Agrp^{tm2(HBEGF)Rpa}/Agrp⁺ Slc17a6^tm1.1Thna/Slc17a6^tm1.1Thna	involves: 129S4/SvJaeSor * C57BL/6J	MGI:5427452
cn6	Agrp^tm1(cre)Lowl/Agrp⁺ Lepr^tm1.1Chua/Lepr^tm1.1Chua	involves: 129S6/SvEvTac	MGI:5142228
cn7	Agrp^tm1(cre)Lowl/Agrp⁺ Slc32a1^tm1Lowl/Slc32a1^tm1Lowl	involves: 129S6/SvEvTac * C57BL/6	MGI:3815087
cn8	Agrp^tm1(cre)Lowl/Agrp⁺ Slc32a1^tm1Lowl/Slc32a1^tm1Lowl Tg(Pomc1-hrGFP)1Lowl/0	involves: 129S6/SvEvTac * FVB/N	MGI:5142231
cn9	Agrp^tm1(cre)Lowl/Agrp⁺ Lepr^tm1.1Chua/Lepr^tm1.1Chua Tg(Pomc1-hrGFP)1Lowl/0	involves: 129S6/SvEvTac * FVB/N	MGI:5142229
cx10	Agrp^{tm2(HBEGF)Rpa}/Agrp⁺ Lep^ob/Lep^ob	involves: 129S4/SvJaeSor * C57BL/6	MGI:5319636
cx11	Agrp^{tm2(HBEGF)Rpa}/Agrp⁺ Tg(Pomc-EGFP)1Low/0	involves: 129S4/SvJaeSor * C57BL/6J	MGI:3776092
cx12	A^y/a Agrp^{tm2(HBEGF)Rpa}/Agrp⁺	involves: 129S4/SvJaeSor * KK/Upj	MGI:3776093

Allelic Composition	Agrp^{tm2(HBEGF)Rpa}/Agrp⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrp^{tm2(HBEGF)Rpa} mutation (1 available); any Agrp mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal eating behavior ( J:132360 )

• adults injected with diptheria toxin (DT) to specifically ablate NPY-expressing cells cease to eat unlike similarly treated wild-type mice

• however, food consumption of neonates following injection with diptheria toxin to specifically ablate NPY-expressing cells is normal

growth/size/body

decreased body weight ( J:132360 )

• neonates injection with diptheria toxin (DT) to specifically ablate NPY-expressing cells exhibit an 11% decreased in body weight at weaning compared to similarly treated wild-type mice

Allelic Composition	Agrp^{tm2(HBEGF)Rpa}/Agrp⁺ Grin1^tm2Stl/Grin1^tm2Stl
Genetic Background	involves: 129S4/SvJae * 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrp^{tm2(HBEGF)Rpa} mutation (1 available); any Agrp mutation (17 available)
Grin1^tm2Stl mutation (1 available); any Grin1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal eating behavior ( J:182577 )

• diphtheria-treated mice bilaterally injected with a virus expressing a AAV1-CreGFP into the parabrachial nucleus

growth/size/body

abnormal postnatal growth/weight/body size ( J:182577 )

• diphtheria-treated mice injected with a virus expressing a AAV1-CreGFP into the nucleus tractus solitaries or parabrachial nucleus prevents starvation induced by AgRP neuron ablation unlike in control mice

Allelic Composition	Agrp^{tm2(HBEGF)Rpa}/Agrp⁺ Tph2^tm1Mscl/Tph2^tm1Mscl
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrp^{tm2(HBEGF)Rpa} mutation (1 available); any Agrp mutation (17 available)
Tph2^tm1Mscl mutation (0 available); any Tph2 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal eating behavior ( J:182577 )

• in diphtheria-treated mice injected with a virus expressing a CAV2-cre into the nucleus tractus solitaries

growth/size/body

abnormal postnatal growth/weight/body size ( J:182577 )

• diphtheria-treated mice injected with a virus expressing a CAV2-cre into the nucleus tractus solitaries prevents starvation induced by AgRP neuron ablation unlike in control mice

homeostasis/metabolism

decreased serotonin level ( J:182577 )

• in diphtheria-treated mice injected with a virus expressing a CAV2-cre into the nucleus tractus solitaries

Allelic Composition	Rock1^tm1.1Itl/Rock1^tm1.1Itl Agrp^tm1(cre)Lowl/Agrp⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrp^tm1(cre)Lowl mutation (1 available); any Agrp mutation (17 available)
Rock1^tm1.1Itl mutation (0 available); any Rock1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total body fat amount ( J:204885 )

increased epididymal fat pad weight ( J:204885 )

increased mesenteric fat pad weight ( J:204885 )

increased renal fat pad weight ( J:204885 )

• perirenal

growth/size/body

increased body weight ( J:204885 )

obese ( J:204885 )

Allelic Composition	Agrp^{tm2(HBEGF)Rpa}/Agrp⁺ Slc17a6^tm1.1Thna/Slc17a6^tm1.1Thna
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrp^{tm2(HBEGF)Rpa} mutation (1 available); any Agrp mutation (17 available)
Slc17a6^tm1.1Thna mutation (0 available); any Slc17a6 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

abnormal postnatal growth/weight/body size ( J:182577 )

increased body weight ( J:182577 )

• mice injected with a virus expressing a AAV1-CreGFP into the parabrachial nucleus without ablation of AgRP neurons

behavior/neurological

abnormal eating behavior ( J:182577 )

• mice injected with a virus expressing a AAV1-CreGFP into the parabrachial nucleus whether treated with diphtheria or not

• in diphtheria treated mice bilaterally with a virus expressing a AAV1-CreGFP into the nucleus tractus solitaries

Allelic Composition	Agrp^tm1(cre)Lowl/Agrp⁺ Lepr^tm1.1Chua/Lepr^tm1.1Chua
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrp^tm1(cre)Lowl mutation (1 available); any Agrp mutation (17 available)
Lepr^tm1.1Chua mutation (1 available); any Lepr mutation (122 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:174691 )

N	• no change in spontaneous IPSC amplitude or frequency is observed in Pomc1 neurons in slices

Allelic Composition	Agrp^tm1(cre)Lowl/Agrp⁺ Slc32a1^tm1Lowl/Slc32a1^tm1Lowl
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrp^tm1(cre)Lowl mutation (1 available); any Agrp mutation (17 available)
Slc32a1^tm1Lowl mutation (1 available); any Slc32a1 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal inhibitory postsynaptic currents ( J:140858 )

• absent in AgRP neurons

growth/size/body

decreased body weight ( J:140858 )

• in both males and females on a normal chow diet

decreased susceptibility to diet-induced obesity ( J:140858 )

• decrease in weight gain when place on a high fat diet

adipose tissue

decreased total body fat amount ( J:140858 )

• decrease in weight gain on a high fat diet is solely the result of reduced fat accumulation

behavior/neurological

abnormal food intake ( J:140858 )

• attenuated response to gherlin induced increase in food intake

• however, no difference in baseline food intake is detected

increased locomotor activity ( J:140858 )

• increased locomotor activity

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:140858 )

• decrease in weight gain when place on a high fat diet

increased oxygen consumption ( J:140858 )

• on a normal chow diet

• during the transition from a normal chow diet to a high fat diet there is a larger increase in oxygen consumption compared to controls

decreased respiratory quotient ( J:140858 )

• reduced

Allelic Composition	Agrp^tm1(cre)Lowl/Agrp⁺ Slc32a1^tm1Lowl/Slc32a1^tm1Lowl Tg(Pomc1-hrGFP)1Lowl/0
Genetic Background	involves: 129S6/SvEvTac * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:174691 )

N	• addition of leptin produces similar inhibition of sIPSCs in neurons to that observed in control preparations

Allelic Composition	Agrp^tm1(cre)Lowl/Agrp⁺ Lepr^tm1.1Chua/Lepr^tm1.1Chua Tg(Pomc1-hrGFP)1Lowl/0
Genetic Background	involves: 129S6/SvEvTac * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:174691 )

N	• addition of leptin produces similar inhibition of sIPSCs in neurons to that observed in control preparations

Allelic Composition	Agrp^{tm2(HBEGF)Rpa}/Agrp⁺ Lep^ob/Lep^ob
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrp^{tm2(HBEGF)Rpa} mutation (1 available); any Agrp mutation (17 available)
Lep^ob mutation (5 available); any Lep mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:181947 )

• young adult mice stop eating and would succumb following treatment with diptheria toxin

• older moderately obese (35-40 g) mice survive diptheria toxin treatment despite weight loss

• however, mice that weigh over 40 g succumb following treatment with diptheria toxin

• norepinephrine treatment prevents prolongs the survival of diptheria toxin treated mice that weigh over 40 g

nervous system

decreased neuron number ( J:181947 )

• loss of agouti-related protein expressing neurons following treatment with diptheria toxin

behavior/neurological

abnormal eating behavior ( J:181947 )

• following treatment with diptheria toxin young adult mice gradually stop eating by day 6 post treatment

• older, moderately obese mice that are able to survive the weight loss resume feeding about 18 days after treatment

growth/size/body

decreased body weight ( J:181947 )

• diptheria toxin treated older moderately obese mice weigh less than saline treated controls for several months after treatment

weight loss ( J:181947 )

• following treatment with diptheria toxin mice lose 20% of their body weight

homeostasis/metabolism

decreased body temperature ( J:181947 )

• diptheria toxin treatment of mice that weigh over 40 g results in a sharp drop in body temperature to near ambient temperature as mice become moribund

• norepinephrine treatment prevents the drop in body temperature

improved glucose tolerance ( J:181947 )

• glucose tolerance is improved in diptheria toxin treated mice relative to saline treated controls and is not significantly different from mice heterozygous for Lep^ob alone

reproductive system

enhanced fertility ( J:181947 )

• following diptheria toxin treatment of older moderately obese mice, both males and females become fertile, unlike saline treated mice which remain infertile

Allelic Composition	Agrp^{tm2(HBEGF)Rpa}/Agrp⁺ Tg(Pomc-EGFP)1Low/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrp^{tm2(HBEGF)Rpa} mutation (1 available); any Agrp mutation (17 available)
Tg(Pomc-EGFP)1Low mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:132184 )

• adult mice treated with diptheria toxin (DT) to specifically ablate NPY-expressing cells exhibit 20% of their body weight unlike similarly treated wild-type mice

nervous system

abnormal inhibitory postsynaptic currents ( J:132184 )

• mice treated with diptheria toxin (DT) to specifically ablate NPY-expressing cells exhibit miniature inhibitory postsynaptic currents that are 6-fold lower than in wild-type mice and lower than in fasted wild-type mice

Allelic Composition	A^y/a Agrp^{tm2(HBEGF)Rpa}/Agrp⁺
Genetic Background	involves: 129S4/SvJaeSor * KK/Upj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (464 available)
Agrp^{tm2(HBEGF)Rpa} mutation (1 available); any Agrp mutation (17 available)
A^y mutation (12 available); any a mutation (464 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal eating behavior ( J:132184 )

• in mice treated with diptheria toxin (DT) to specifically ablate NPY-expressing cells

growth/size/body

decreased body weight ( J:132184 )

• in mice treated with diptheria toxin (DT) to specifically ablate NPY-expressing cells

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