All Phenotypes Nfat5<+> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Nfat5^{tm1b(KOMP)Wtsi}/Nfat5⁺	C57BL/6N-Nfat5^{tm1b(KOMP)Wtsi}/J	MGI:6263010
ht2	Nfat5^tm1Snh/Nfat5⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3051136

Allelic Composition	Nfat5^{tm1b(KOMP)Wtsi}/Nfat5⁺
Genetic Background	C57BL/6N-Nfat5^{tm1b(KOMP)Wtsi}/J
Cell Lines	EPD0503_4_F01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfat5^{tm1b(KOMP)Wtsi} mutation (1 available); any Nfat5 mutation (63 available)

Data Sources

IMPC Data for Nfat5

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased hematocrit ( J:211773 )

IMPC - JAX

homeostasis/metabolism

increased circulating bilirubin level ( J:211773 )

IMPC - JAX

increased circulating sodium level ( J:211773 )

IMPC - JAX

improved glucose tolerance ( J:211773 )

IMPC - JAX

increased circulating chloride level ( J:211773 )

IMPC - JAX

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased T cell proliferation ( J:91482 )

• proliferation of T cells is reduced in hypertonic and hyperosmotic conditions but not in isosmotic or isotonic conditions

thymus hypoplasia ( J:91482 )

• thymus cellularity is reduced by 40% compared to wild-type littermates

spleen hypoplasia ( J:91482 )

• spleen cellularity is reduced by 32% compared to wild-type littermates

abnormal immunoglobulin level ( J:91482 )

• antigen specific antibody production is reduced 44% compared to wild-type mice

decreased IgG level ( J:91482 )

• total serum IgG but not IgM levels are reduced by 35%

immune system

decreased T cell proliferation ( J:91482 )

• proliferation of T cells is reduced in hypertonic and hyperosmotic conditions but not in isosmotic or isotonic conditions

thymus hypoplasia ( J:91482 )

• thymus cellularity is reduced by 40% compared to wild-type littermates

spleen hypoplasia ( J:91482 )

• spleen cellularity is reduced by 32% compared to wild-type littermates

abnormal immunoglobulin level ( J:91482 )

• antigen specific antibody production is reduced 44% compared to wild-type mice

decreased IgG level ( J:91482 )

• total serum IgG but not IgM levels are reduced by 35%

endocrine/exocrine glands

thymus hypoplasia ( J:91482 )

• thymus cellularity is reduced by 40% compared to wild-type littermates

cellular

decreased T cell proliferation ( J:91482 )

• proliferation of T cells is reduced in hypertonic and hyperosmotic conditions but not in isosmotic or isotonic conditions

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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