All Phenotypes Hoxc13<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxc13⁺
wild type
MGI:2440028

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hoxc13^N/Hoxc13⁺	Not Specified	MGI:3609056
ht2	Hoxc13^tm2Mrc/Hoxc13⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:3653722
ht3	Hoxc13^tm3Mrc/Hoxc13⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3832428
ht4	Hoxc13^tm3.1Mrc/Hoxc13⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3832430
ht5	Hoxc13^tm1Mrc/Hoxc13⁺	involves: 129S7/SvEvBrd	MGI:3653721

Allelic Composition	Hoxc13^N/Hoxc13⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxc13^N mutation (0 available); any Hoxc13 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal coat appearance ( J:14908 )

• hair breakage and regeneration is not uniform so mice are mosaic for bare and haired patches

abnormal hair texture ( J:14908 )

brittle hair ( J:14908 )

• hair begins to break at 10 to 14 days due to incomplete keratinization

• hair breakage and regeneration occurs in cycles

abnormal hair shaft morphology ( J:6403 , J:14908 , J:30359 )

• hair shafts have a deficiency in or entirely lack a cuticle (J:30359)

abnormal hair cuticle ( J:30359 )

• may be deficient or absent

abnormal hair cycle ( J:6403 )

abnormal epidermal layer morphology ( J:6403 )

• dermal-epidermal recombination experiments indicated that the epidermis of this mutant is abnormal

• one or more weak places result in breakage or longitudinal fissures

Allelic Composition	Hoxc13^tm2Mrc/Hoxc13⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxc13^tm2Mrc mutation (0 available); any Hoxc13 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal axial skeleton morphology ( J:45400 )

• adult heterozygotes have no appendicular skeleton defects but show an increased number of caudal vertebrae with lateral processes

caudal vertebral transformation ( J:45400 )

• adult heterozygotes display 6-7 caudal vertebrae with lateral processes whereas wild-type mice have only 4-5; however, no increase in the total number of caudal vertebrae is observed, suggesting a true homeotic transformation

limbs/digits/tail

caudal vertebral transformation ( J:45400 )

Allelic Composition	Hoxc13^tm3Mrc/Hoxc13⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxc13^tm3Mrc mutation (0 available); any Hoxc13 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

focal hair loss ( J:50569 )

• at some stages of the hair cycle, lower portions of the face, especially below and behind the eyes, show patchy fur

sparse hair ( J:50569 )

• the ventral coat is sparse, especially in females

• dorsal coat appears relatively normal

Allelic Composition	Hoxc13^tm3.1Mrc/Hoxc13⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxc13^tm3.1Mrc mutation (0 available); any Hoxc13 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

focal hair loss ( J:50569 )

• at some stages of the hair cycle, lower portions of the face, especially below and behind the eyes, show patchy fur

sparse hair ( J:50569 )

• the ventral coat is sparse, especially in females

• dorsal coat appears relatively normal

Allelic Composition	Hoxc13^tm1Mrc/Hoxc13⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxc13^tm1Mrc mutation (0 available); any Hoxc13 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal axial skeleton morphology ( J:45400 )

• adult heterozygotes have no appendicular skeleton defects but show an increased number of caudal vertebrae with lateral processes

caudal vertebral transformation ( J:45400 )

limbs/digits/tail

caudal vertebral transformation ( J:45400 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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