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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Abhd2+
wild type
MGI:2440168
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Abhd2em1Lshko/Abhd2+ C57BL/6N-Abhd2em1Lshko MGI:7413907


Genotype
MGI:7413907
ht1
Allelic
Composition		 Abhd2em1Lshko/Abhd2+
Genetic
Background		 C57BL/6N-Abhd2em1Lshko
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abhd2em1Lshko mutation (0 available); any Abhd2 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
increased granulosa cell apoptosis ( J:322075 )
• TUNEL staining showed increased labeling of granulosa cells in follicles going through atresia
increased corpora lutea number ( J:322075 )
• ovaries from 3.5-month-old mice show significantly higher numbers of corpora lutea in proestrus than ovaries from wild-type females
increased mature ovarian follicle number ( J:322075 )
• ovaries from 3.5-month-old mice show significantly higher numbers of antral pre-ovulatory follicles in proestrus than ovaries from wild-type females
decreased tertiary ovarian follicle number ( J:322075 )
• ovaries from 3.5-month-old mice show significantly lower numbers of early antral follicles in proestrus than ovaries from wild-type females
increased atretic ovarian follicle number ( J:322075 )
• ovaries exhibit a higher number of atretic antral follicles than wild-type ovaries
• however, the total number of healthy follicles is normal
increased superovulation rate ( J:322075 )
• after induction of superovulation with PMSG + hCG, 1-month-old females produce a significantly higher number of ovulated eggs than wild-type controls
• however, IVF studies show a comparable success rate in blastula formation as when using eggs from wild-type females

endocrine/exocrine glands
increased granulosa cell apoptosis ( J:322075 )
• TUNEL staining showed increased labeling of granulosa cells in follicles going through atresia
increased corpora lutea number ( J:322075 )
• ovaries from 3.5-month-old mice show significantly higher numbers of corpora lutea in proestrus than ovaries from wild-type females
increased mature ovarian follicle number ( J:322075 )
• ovaries from 3.5-month-old mice show significantly higher numbers of antral pre-ovulatory follicles in proestrus than ovaries from wild-type females
decreased tertiary ovarian follicle number ( J:322075 )
• ovaries from 3.5-month-old mice show significantly lower numbers of early antral follicles in proestrus than ovaries from wild-type females
increased atretic ovarian follicle number ( J:322075 )
• ovaries exhibit a higher number of atretic antral follicles than wild-type ovaries
• however, the total number of healthy follicles is normal

cellular
increased granulosa cell apoptosis ( J:322075 )
• TUNEL staining showed increased labeling of granulosa cells in follicles going through atresia




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory