Phenotypes associated with this allele

• Allele Symbol: Gdf11⁺
• Allele Name: wild type
• Allele ID: MGI:2440320
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gdf11^tm2b(EUCOMM)Hmgu/Gdf11^+	C57BL/6N-Gdf11^tm2b(EUCOMM)Hmgu/Bay	MGI:6461289
ht2	Gdf11^tm1Sjl/Gdf11^+	involves: 129S1/Sv * 129X1/SvJ	MGI:3589479
ht3	Gdf11^tm1Sjl/Gdf11^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3589669
ht4	Gdf11^tm2.2Sjl/Gdf11^+	involves: C57BL/6 * CBA * FVB	MGI:4438570

Genotype
MGI:6461289

ht1

• Allelic Composition: Gdf11^{tm2b(EUCOMM)Hmgu}/Gdf11⁺
• Genetic Background: C57BL/6N-Gdf11^{tm2b(EUCOMM)Hmgu}/Bay
• Cell Lines: HEPD0802_3_E05

Data Sources

IMPC Data for Gdf11

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased cardiac stroke volume ( J:211773 )

♀

IMPC - BCM

vision/eye

abnormal retina morphology ( J:211773 )

IMPC - BCM

Genotype
MGI:3589479

ht2

• Allelic Composition: Gdf11^tm1Sjl/Gdf11⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

skeleton

abnormal axial skeleton morphology ( J:55879 )

• in general, heterozygotes exhibit milder anterior transformations in the axial skeleton relative to homozygous mutant mice

asymmetric rib joints ( J:55879 )

increased rib number ( J:55879 )

• heterozygotes exhibit an extra thoracic segment with an associated pair of ribs, which is almost always attached to the sternum

thoracic vertebral transformation ( J:55879 )

• heterozygotes display an additional thoracic segment with an associated pair of ribs, with T8 being transformed to a more anterior thoracic segment

• anterior transformations include a shift of the long spinous process characteristic of T2 by one segment to T3, a shift of the transitional articular and spinous processes from T10 to T11, and transformation of T2 to T1, in which the rib associated with T2 touches the top of the sternum

abnormal cervical vertebrae morphology ( J:55879 )

• heterozygotes exhibit an asymmetric shift of an anterior tuberculus on C6 to C7

lumbar vertebral transformation ( J:55879 )

• in heterozygotes, L1 appears to be transformed to a posterior thoracic segment

renal/urinary system

abnormal kidney development ( J:83365 )

single kidney ( J:83365 )

• a small % of heterozygotes (5 out of 93) display unilateral renal agenesis

absent ureter ( J:83365 )

• all heterozygotes lacking a kidney on one side also display loss of the corresponding ureter

Genotype
MGI:3589669

ht3

• Allelic Composition: Gdf11^tm1Sjl/Gdf11⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Axial skeleton patterning defects in Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl, Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl Fst^tm1Zuk/Fst^tm1Zuk, Gdf11^tm1Sjl/Gdf11⁺ and Gdf11^tm1Sjl/Gdf11^tm1Sjl mice.

endocrine/exocrine glands

increased pancreatic alpha cell mass ( J:94455 )

• at E17.5 and P1, heterozygotes exhibit a ~3-fold increase in total alpha-cell mass

• no reduction in total beta-cell mass or significant changes in the numbers of cells expressing somatostatin or pancreatic polypeptide were observed

increased pancreatic islet number ( J:94455 )

• at E17.5 and P1, heterozygotes display a slight increase in islet number relative to wild-type mice

• heterozygotes exhibit increased numbers of pancreatic cells expressing NGN3, HNF6 or glucagon in the absence of gross defects in stomach, spleen or other foregut-derived organs

small pancreatic islets ( J:94455 )

• at E17.5 and P1, heterozygous pancreatic islets are reduced in size relative to wild-type islets

• notably, heterozygotes display premature expansion and increased numbers of neurogenin-3 positive pancreatic cells (3-fold at E15.5-E17.5)

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:94455 )

N • both random-fed and glucose-challenged heterozygotes display normal glucose regulation after weaning

craniofacial

cleft palate ( J:201148 )

• in 2 of 3 mice

skeleton

abnormal sternocostal joint morphology ( J:201148 )

• ribs are attached down to T14

increased rib number ( J:201148 )

• ribs are present down to T14

digestive/alimentary system

cleft palate ( J:201148 )

• in 2 of 3 mice

growth/size/body

cleft palate ( J:201148 )

• in 2 of 3 mice

Genotype
MGI:4438570

ht4

• Allelic Composition: Gdf11^tm2.2Sjl/Gdf11⁺
• Genetic Background: involves: C57BL/6 * CBA * FVB

skeleton

increased thoracic vertebrae number ( J:158173 )

• mice exhibit an extra thoracic vertebrae compared with wild-type mice