Phenotypes associated with this allele

• Allele Symbol: Was⁺
• Allele Name: wild type
• Allele ID: MGI:2440843
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd79a^tm1(cre)Reth/Cd79a^+ Was^tm1.1Ldn/Was^+	involves: BALB/c * C57BL/6	MGI:5319486

Genotype
MGI:5319486

cn1

• Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺; Was^tm1.1Ldn/Was⁺
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell proliferation ( J:182528 )

♀ • increased proliferation in cells lacking expression of Was compared to cells expressing Was in the follicular and germinal center B cell populations

abnormal B cell number ( J:182528 )

♀ • while B cell numbers are similar to controls, the distribution of cells lacking expression of Was is biased against marginal zone B cells

♀ • enrichment of null cells in the germinal center cell and plasma cell populations

hematopoietic system

abnormal B cell proliferation ( J:182528 )

♀ • increased proliferation in cells lacking expression of Was compared to cells expressing Was in the follicular and germinal center B cell populations

abnormal B cell number ( J:182528 )

♀ • while B cell numbers are similar to controls, the distribution of cells lacking expression of Was is biased against marginal zone B cells

♀ • enrichment of null cells in the germinal center cell and plasma cell populations

cellular

abnormal B cell proliferation ( J:182528 )

♀ • increased proliferation in cells lacking expression of Was compared to cells expressing Was in the follicular and germinal center B cell populations