Analysis Tools
cellular
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• at P5, there is a decrease in the number of apoptotic cells in the retina
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• the number of apoptotic cells is increased in the retina at E17.5
• however, at P5, there is a decrease in the number of apoptotic cells
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vision/eye
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• many spots and patchy areas are visible throughout the retina (pseudo-rosettes)
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• disruption of the apical adherens junctions/subapical region in retinas at E15.5 which leads to ectopic localization of some photoreceptor and bipolar cells in the ganglion cell layer and ganglion, amacrine, and bipolar cells in the outer nuclear layer
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• ganglion cell nuclei and inner nuclear layer cells are seen in the outer nuclear layer and some photoreceptor nuclei are seen in the ganglion cell layer
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• rods, cones and bipolar cells localize ectopically in the ganglion cell layer
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• amacrine and ganglion cells surrounded by bipolar cells form pseudo-rosettes in the photoreceptor layer
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• the outer limiting membrane is perturbed at the periphery of the retina at E15.5, and progressively extends to the center of the retinas where rosettes form
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• the number of mitotic cells is increased in the retina at E17.5 and at P5
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• at P5, there is a decrease in the number of apoptotic cells in the retina
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• the number of apoptotic cells is increased in the retina at E17.5
• however, at P5, there is a decrease in the number of apoptotic cells
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• mice exhibit a greater reduction in amplitudes of electroretinogram responses at 1 month of age than single Crb2 conditional mutants, with both scotopic and photopic responses
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Leber congenital amaurosis 8 | DOID:0110079 |
OMIM:613835 |
J:207895 | |
