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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atf1tm1Gsc
targeted mutation 1, Gunther Schutz
MGI:2445229
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Atf1tm1Gsc/Atf1tm1Gsc involves: 129/Sv * C57BL/6 MGI:2655597
cn2
 		Atf1tm1Gsc/Atf1tm1Gsc
Creb1tm3Gsc/Creb1tm3Gsc
Tg(Dbh-icre)1Gsc/0 		involves: 129 * 129P2/OlaHsd * C57BL/6 MGI:4355665
cx3
 		Atf1tm1Gsc/Atf1tm1Gsc
Creb1tm2Gsc/Creb1tm2Gsc 		involves: 129/Sv * 129P2/SvPas * C57BL/6 MGI:2655603
cx4
 		Atf1tm1Gsc/Atf1+
Creb1tm2Gsc/Creb1tm2Gsc 		involves: 129/Sv * 129P2/SvPas * C57BL/6 MGI:2655606
cx5
 		Atf1tm1Gsc/Atf1+
Creb1tm2Gsc/Creb1+ 		involves: 129/Sv * 129P2/SvPas * C57BL/6 MGI:3047273
cx6
 		Atf1tm1Gsc/Atf1tm1Gsc
Creb1tm2Gsc/Creb1+ 		involves: 129/Sv * 129P2/SvPas * C57BL/6 MGI:3047274


Genotype
MGI:2655597
hm1
Allelic
Composition		 Atf1tm1Gsc/Atf1tm1Gsc
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf1tm1Gsc mutation (1 available); any Atf1 mutation (209 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:74982 )
• mice are fertile, with no abnormalities detected; no defects were detected in histology of all major organs and tissues




Genotype
MGI:4355665
cn2
Allelic
Composition		 Atf1tm1Gsc/Atf1tm1Gsc
Creb1tm3Gsc/Creb1tm3Gsc
Tg(Dbh-icre)1Gsc/0
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf1tm1Gsc mutation (1 available); any Atf1 mutation (209 available)
Creb1tm3Gsc mutation (2 available); any Creb1 mutation (61 available)
Tg(Dbh-icre)1Gsc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased neuron apoptosis ( J:121244 )
• number of caspase 3-positive (apoptotic) cells is decreased compared to controls in the SCG at E17.5

cellular
decreased neuron apoptosis ( J:121244 )
• number of caspase 3-positive (apoptotic) cells is decreased compared to controls in the SCG at E17.5




Genotype
MGI:2655603
cx3
Allelic
Composition		 Atf1tm1Gsc/Atf1tm1Gsc
Creb1tm2Gsc/Creb1tm2Gsc
Genetic
Background		 involves: 129/Sv * 129P2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf1tm1Gsc mutation (1 available); any Atf1 mutation (209 available)
Creb1tm2Gsc mutation (1 available); any Creb1 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cellular
abnormal apoptosis ( J:74982 )
• apoptosis was detected in most blastomere cells

embryo
failure of blastocyst to hatch from the zona pellucida ( J:74982 )
• these embryos did not develop to the blastocyst stage and did not hatch from the zona pellucida
abnormal blastocyst morphology ( J:74982 )
• preimplantation embryos had a morula appearance with no blastocoel or ICM seen




Genotype
MGI:2655606
cx4
Allelic
Composition		 Atf1tm1Gsc/Atf1+
Creb1tm2Gsc/Creb1tm2Gsc
Genetic
Background		 involves: 129/Sv * 129P2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf1tm1Gsc mutation (1 available); any Atf1 mutation (209 available)
Creb1tm2Gsc mutation (1 available); any Creb1 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:74982 )
• embryos die due to massive apoptosis

cellular
abnormal apoptosis ( J:74982 )
• apoptosis was detected in most cells present at E7.5

embryo
abnormal germ layer development ( J:74982 )
• at E7.5, embryos lack differentiated germ cell layers; at E9.5, some differentiated cells were seen, but no organized cell layers were apparent
delayed blastocyst hatching from the zona pellucida ( J:74982 )
• these embryos exhibited delayed hatching from the zona pellucida
absent egg cylinders ( J:74982 )
• an accumulation of cells at the distal end of conceptus was noted
abnormal blastocyst morphology ( J:74982 )
• preimplantation embryos had a morula appearance with no blastocoel or ICM seen
• however, the trophoblast forms normally




Genotype
MGI:3047273
cx5
Allelic
Composition		 Atf1tm1Gsc/Atf1+
Creb1tm2Gsc/Creb1+
Genetic
Background		 involves: 129/Sv * 129P2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf1tm1Gsc mutation (1 available); any Atf1 mutation (209 available)
Creb1tm2Gsc mutation (1 available); any Creb1 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:74982 )
• mice did not exhibit any abnormalities




Genotype
MGI:3047274
cx6
Allelic
Composition		 Atf1tm1Gsc/Atf1tm1Gsc
Creb1tm2Gsc/Creb1+
Genetic
Background		 involves: 129/Sv * 129P2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf1tm1Gsc mutation (1 available); any Atf1 mutation (209 available)
Creb1tm2Gsc mutation (1 available); any Creb1 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:74982 )
• no phenotypic or histological abnormalities were detected




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory