Phenotypes associated with this allele

• Allele Symbol: Gja5^tm1Kwi
• Allele Name: targeted mutation 1, Klaus Willecke
• Allele ID: MGI:2445238
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gja5^tm1Kwi/Gja5^tm1Kwi	involves: 129S4/SvJae * C57BL/6	MGI:3621216

Genotype
MGI:3621216

hm1

• Allelic Composition: Gja5^tm1Kwi/Gja5^tm1Kwi
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart rate ( J:46429 )

• 1 of 31 homozygotes showed high frequency intra-atrial re-entrant tachycardia

irregular heartbeat ( J:46429 )

• 6 out of 31 homozygotes exhibited disturbances of pulse generation and/or sinoatrial and AV pulse propagation

abnormal impulse conducting system conduction ( J:46429 )

• homozygotes exhibited significantly prolonged ECG parameters, indicating reduced atrial, atrioventricular, and ventricular conduction velocities

• however, no significant differences in the frequency of heart beat were observed

prolonged P wave ( J:46429 )

• ECG recordings indicated significantly prolonged P waves (+57%)

prolonged PQ interval ( J:46429 )

• ECG recordings indicated significantly prolonged PQ intervals (+18%)

prolonged QRS complex duration ( J:46429 )

• ECG recordings indicated significantly prolonged QS intervals (+46%)

prolonged QT interval ( J:46429 )

• ECG recordings indicated significantly prolonged QTmax intervals (+50%)