Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbxa2rtm1Cof mutation
(0 available);
any
Tbxa2r mutation
(18 available)
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cardiovascular system
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• in response to catheter-induced carotid vascular injury, homozygotes exhibit attenuated vascular proliferative indices, as shown by a significant reduction in the intima-to-media ratio, % lumen stenosis, number of intimal BrdU-labeled proliferative cells, and platelet activation
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hematopoietic system
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• in response to catheter-induced carotid vascular injury, homozygotes display reduced platelet activation, as shown by a reduced injury-related increment in urinary excretion of metabolite 2,3-dinor-TxB2
• these findings are consistent with data obtained with antagonist S18886
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homeostasis/metabolism
Allelic
Composition |
Tbxa2rtm1Cof/Tbxa2rtm1Cof
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Genetic
Background |
either: (involves: 129P2/OlaHsd * C57BL/6 * DBA/2) or (involves: 129P2/OlaHsd * 129S/SvEv) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbxa2rtm1Cof mutation
(0 available);
any
Tbxa2r mutation
(18 available)
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mortality/aging
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N |
• homozygotes are born in the expected Mendelian ratios and appear normal and healthy without histological abnormalities in major organ systems
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homeostasis/metabolism
cardiovascular system
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• i.v. infusion with agonist U-46619 causes transient increases in blood pressure followed by cardiovascular collapse in wild-type but NOT in mutant mice
• homozygotes are also resistant to the hemodynamic collapse induced by arachidonic acid, although mean arterial pressure is reduced by ~25 mmHg
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hematopoietic system
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• homozygotes fail to exhibit platelet aggregation responses upon induction with agonist U-46619
• after collagen treatment, homozygotes display a prolonged delay prior to the onset of platelet aggregation, although maximum aggregation is similar between wild-type and mutant mice
• no differences in platelet aggregation responses induced by addition of ADP to platelet-rich plasma are observed
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reproductive system
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N |
• despite high levels of expression in the placenta and uterus, homozygotes show no significant differences in fertility, pregnancy, gestation, delivery or litter size relative to wild-type mice
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immune system
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N |
• homozygotes exhibit normal thymic architecture and cellular composition relative to wild-type mice
• no differences in the number of total T cells, CD4+ T cells, CD8+ T cells, B cells, or macrophages are observed in spleen
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbxa2rtm1Cof mutation
(0 available);
any
Tbxa2r mutation
(18 available)
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respiratory system
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• mice exposed to increasing doses of thromboxane receptor agonist U-46619 fail to exhibit a dose-dependent increase in airway resistance unlike control mice
• mice exposed to U-46619 and methacholine fail to exhibit increased airway resistance unlike control mice
• mice exposed to ovalbumin and U-46619 fail to exhibit increased airway resistance unlike control mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbxa2rtm1.1Bhk mutation
(1 available);
any
Tbxa2r mutation
(18 available)
Tbxa2rtm1Cof mutation
(0 available);
any
Tbxa2r mutation
(18 available)
Tg(Nes-cre)1Kln mutation
(4 available)
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respiratory system
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• mice exposed to ovalbumin and U-46619 fail to exhibit increased airway resistance unlike control mice
• however, mice exposed to increasing doses of thromboxane receptor agonist U-46619 exhibit dose-dependent increase in airway resistance
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbxa2rtm1.1Bhk mutation
(1 available);
any
Tbxa2r mutation
(18 available)
Tbxa2rtm1Cof mutation
(0 available);
any
Tbxa2r mutation
(18 available)
Tg(Tagln-cre)1Her mutation
(2 available)
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respiratory system
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• mice exposed to increasing doses of thromboxane receptor agonist U-46619 exhibit an attenuated dose-dependent increase in airway resistance unlike control mice
• mice exposed to U-46619 and methacholine exhibit less of an increased in airway resistance compared with control mice
• however, mice exposed ovalbumin and U-46619 exhibit dose-dependent increase in airway resistance
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgirtm1Sna mutation
(1 available);
any
Ptgir mutation
(32 available)
Tbxa2rtm1Cof mutation
(0 available);
any
Tbxa2r mutation
(18 available)
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cardiovascular system
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N |
• following catheter-induced carotid vascular injury, double homozygotes fail to exhibit the enhanced vascular proliferative response observed in Ptgirtm1Sna homozygotes
• in double homozygotes, the intima-to-media ratio, % of luminal stenosis, and the number of BrdU-labeled cells is comparable to observed in wild-type mice; in addition, the periprocedural increment in platelet activation noted in Ptgirtm1Sna homozygotes is abolished
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Analysis Tools