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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cpb2tm1Efp
targeted mutation 1, Edward F Plow
MGI:2445419
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cpb2tm1Efp/Cpb2tm1Efp B6.129-Cpb2tm1Efp MGI:3720814
cx2
 		Cpb2tm1Efp/Cpb2tm1Efp
Plgtm1Dco/Plgtm1Dco 		involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 MGI:3720815
cx3
 		Cpb2tm1Efp/Cpb2+
Plgtm1Dco/Plgtm1Dco 		involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 MGI:3720818
cx4
 		Cpb2tm1Efp/Cpb2+
Plgtm1Dco/Plg+ 		involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 MGI:3720825
cx5
 		Cpb2tm1Efp/Cpb2tm1Efp
Plgtm1Dco/Plg+ 		involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 MGI:3720826


Genotype
MGI:3720814
hm1
Allelic
Composition		 Cpb2tm1Efp/Cpb2tm1Efp
Genetic
Background		 B6.129-Cpb2tm1Efp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpb2tm1Efp mutation (0 available); any Cpb2 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal blood coagulation ( J:80114 )
• in an in vitro assay, fibrin clot digestion is 52.8%+/-1.8% compared to 49.0%+/-1.5% in wild-type extracts and fails to increase with the addition of a potato carboxypeptidase inhibitor (PCI) as in wild-type extracts




Genotype
MGI:3720815
cx2
Allelic
Composition		 Cpb2tm1Efp/Cpb2tm1Efp
Plgtm1Dco/Plgtm1Dco
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpb2tm1Efp mutation (0 available); any Cpb2 mutation (31 available)
Plgtm1Dco mutation (0 available); any Plg mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal blood coagulation ( J:80114 )
• in an in vitro assay, fibrinolysis activity is increased to 54.9%+/-3.7% compared to 2.3%+/-1.1% in Plgtm1Dco homozygotes

growth/size/body
decreased body size ( J:80114 )
• mice are runted and have persistent health problems described for Plgtm1Dco homozygotes




Genotype
MGI:3720818
cx3
Allelic
Composition		 Cpb2tm1Efp/Cpb2+
Plgtm1Dco/Plgtm1Dco
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpb2tm1Efp mutation (0 available); any Cpb2 mutation (31 available)
Plgtm1Dco mutation (0 available); any Plg mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal blood coagulation ( J:80114 )
• in an in vitro assay, fibrinolysis activity exhibits an intermediate increase to 29.3%+/-3.4% compared to 2.3%+/-1.1% in Plgtm1Dco homozygotes and 54.9%+/-3.7% in Cpb2tm1Efp Plgtm1Dco homozygotes




Genotype
MGI:3720825
cx4
Allelic
Composition		 Cpb2tm1Efp/Cpb2+
Plgtm1Dco/Plg+
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpb2tm1Efp mutation (0 available); any Cpb2 mutation (31 available)
Plgtm1Dco mutation (0 available); any Plg mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal blood coagulation ( J:80114 )
• in an in vitro assay, fibrinolysis activity is increased relative to in Plgtm1Dco homozygotes

immune system
abnormal inflammatory response ( J:80114 )
• 72 hours following thioglycollate injection into the peritoneum, recruitment of leukocytes is improved (23.8+/-2.1 x106 leukocytes in the peritoneum compared to 15.0+/-1.3 x106 in Plgtm1Dco heterozygotes and 28.7+/-1.62 x106 in wild-type mice)




Genotype
MGI:3720826
cx5
Allelic
Composition		 Cpb2tm1Efp/Cpb2tm1Efp
Plgtm1Dco/Plg+
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpb2tm1Efp mutation (0 available); any Cpb2 mutation (31 available)
Plgtm1Dco mutation (0 available); any Plg mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal blood coagulation ( J:80114 )
• in an in vitro assay, fibrinolysis activity is increased relative to in Plgtm1Dco homozygotes and in Cpb2tm1Efp Plgtm1Dco heterozygotes

immune system
abnormal inflammatory response ( J:80114 )
• 72 hours following thioglycollate injection into the peritoneum, recruitment of leukocytes is improved (29.5+/-2.7 x106 leukocytes in the peritoneum compared to 15.0+/-1.3 x106 in Plgtm1Dco heterozygotes and 28.7+/-1.62 x106 in wild-type mice)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory