Phenotypes associated with this allele

• Allele Symbol: Tg(COL2A1-cre)1Wag
• Allele Name: transgene insertion 1, Erwin F Wagner
• Allele ID: MGI:2445431
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Jun^tm4Wag/Jun^tm4Wag Tg(COL2A1-cre)1Wag/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:2451284
cn2	Fosl2^tm2Wag/Fosl2^tm2Wag Tg(COL2A1-cre)1Wag/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3522178

Genotype
MGI:2451284

cn1

• Allelic Composition: Jun^tm4Wag/Jun^tm4Wag; Tg(COL2A1-cre)1Wag/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal thoracic cage morphology ( J:80022 )

scoliosis ( J:80022 )

Genotype
MGI:3522178

cn2

• Allelic Composition: Fosl2^tm2Wag/Fosl2^tm2Wag; Tg(COL2A1-cre)1Wag/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

mortality/aging

postnatal lethality, complete penetrance ( J:94393 )

• died between P10 and P25

growth/size/body

decreased body size ( J:94393 )

decreased body weight ( J:94393 )

postnatal growth retardation ( J:94393 )

• growth retardation after P1

skeleton

decreased width of hypertrophic chondrocyte zone ( J:94393 )

• narrower zone of hypertrophic chondrocytes in P5-P23 femoral growth plates

kyphosis ( J:94393 )

• developed kyphosis between P5 and P10

abnormal chondrocyte morphology ( J:94393 )

• reduced zone of proliferating chondrocytes in femoral growth plates at P23 but not at P5 or P10

decreased bone mineralization ( J:94393 )

• smaller mineralized regions in long bones