About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Procrtm1Cte
targeted mutation 1, Charles T Esmon
MGI:2445432
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Procrtm1Cte/Procrtm1Cte either: 129S/SvEv-Procrtm1Cte or (involves: 129S7/SvEvBrd * Black Swiss) MGI:2651883
hm2
 		Procrtm1Cte/Procrtm1Cte involves: 129S7/SvEvBrd MGI:3702948
ht3
 		Procrtm1Cte/Procr+ B6.129S7-Procrtm1Cte MGI:3831372
cn4
 		Meox2tm1(cre)Sor/Meox2+
Procrtm1Cte/Procrtm2Cte 		involves: 129S4/SvJaeSor * 129S7/SvEvBrd * Black Swiss * C57BL/6 MGI:3702950
cx5
 		F3tm1Dco/F3tm1Dco
Procrtm1Cte/Procrtm1Cte 		involves: 129S7/SvEvBrd * BALB/c * Black Swiss * C57BL/6 * FVB/N MGI:3702956
cx6
 		F3tm1Dco/F3tm1Dco
Procrtm1Cte/Procrtm1Cte
Tg(F3)1Nmk/0 		involves: 129S7/SvEvBrd * BALB/c * Black Swiss * C57BL/6 * FVB/N MGI:3702952
cx7
 		Procrtm1Cte/Procrtm1Cte
Tg(F3)1Nmk/0 		involves: 129S7/SvEvBrd * BALB/c * C57BL/6 MGI:3702957
cx8
 		Procrtm1Cte/Procrtm1Cte
Tg(Tek-Procr)1Cte/0 		involves: 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:3703332


Genotype
MGI:2651883
hm1
Allelic
Composition		 Procrtm1Cte/Procrtm1Cte
Genetic
Background		 either: 129S/SvEv-Procrtm1Cte or (involves: 129S7/SvEvBrd * Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Procrtm1Cte mutation (0 available); any Procr mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Procrtm1Cte/Procrtm1Cte embryos are small at E8, growth retarded by E9.5, and do not complete axial rotation

mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:80043 )
• death on or before E10.5
• embryos removed from extraembyronic tissues and cultured in vitro develop beyond E10.5
• anticoagulant treatment fails to fully rescue embryos

embryo
incomplete embryo turning ( J:80043 )
• do not complete axial rotation
• complete axial rotation is observed after anticoagulant treatment
embryonic growth retardation ( J:80043 )
• developmentally growth retarded by E9.5; embryos do not progress past Theiler stage 13
decreased embryo size ( J:80043 )
• smaller in size than wild-type at E8
abnormal extraembryonic tissue morphology ( J:80043 )
• the extra-embryonic membranes are discontinuous at E9.5

growth/size/body
embryonic growth retardation ( J:80043 )
• developmentally growth retarded by E9.5; embryos do not progress past Theiler stage 13
decreased embryo size ( J:80043 )
• smaller in size than wild-type at E8

homeostasis/metabolism
abnormal blood coagulation ( J:80043 )
• fibrin deposition around giant cells, accompanied by infiltration of leukocytes
abnormal placental thrombosis ( J:80043 )
• placental thrombosis




Genotype
MGI:3702948
hm2
Allelic
Composition		 Procrtm1Cte/Procrtm1Cte
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Procrtm1Cte mutation (0 available); any Procr mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:119529 )
• injection of low-molecular weight heparin into pregnant mice from E4.5 to full term partially rescues these pups; 2/48 live born animals are Procrtm1Cte




Genotype
MGI:3831372
ht3
Allelic
Composition		 Procrtm1Cte/Procr+
Genetic
Background		 B6.129S7-Procrtm1Cte
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Procrtm1Cte mutation (0 available); any Procr mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal blood coagulation ( J:144388 )
• activated protein C levels after thrombin infusion are lower than in controls
• slightly reduced fibrinogen levels

hematopoietic system
thrombocytopenia ( J:144388 )
• slightly reduced platelet counts




Genotype
MGI:3702950
cn4
Allelic
Composition		 Meox2tm1(cre)Sor/Meox2+
Procrtm1Cte/Procrtm2Cte
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * Black Swiss * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Procrtm1Cte mutation (0 available); any Procr mutation (17 available)
Procrtm2Cte mutation (0 available); any Procr mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:119529 )
• no Procr-null, Meox2 heterozygous mice are obtained




Genotype
MGI:3702956
cx5
Allelic
Composition		 F3tm1Dco/F3tm1Dco
Procrtm1Cte/Procrtm1Cte
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/c * Black Swiss * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F3tm1Dco mutation (0 available); any F3 mutation (24 available)
Procrtm1Cte mutation (0 available); any Procr mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:119529 )
• no embryos with this genotype are found at birth




Genotype
MGI:3702952
cx6
Allelic
Composition		 F3tm1Dco/F3tm1Dco
Procrtm1Cte/Procrtm1Cte
Tg(F3)1Nmk/0
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/c * Black Swiss * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F3tm1Dco mutation (0 available); any F3 mutation (24 available)
Procrtm1Cte mutation (0 available); any Procr mutation (17 available)
Tg(F3)1Nmk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:119529 )
N
• mice are born at expected frequency and survive at least 8 months




Genotype
MGI:3702957
cx7
Allelic
Composition		 Procrtm1Cte/Procrtm1Cte
Tg(F3)1Nmk/0
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Procrtm1Cte mutation (0 available); any Procr mutation (17 available)
Tg(F3)1Nmk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:119529 )
• no embryos with this genotype are found at birth




Genotype
MGI:3703332
cx8
Allelic
Composition		 Procrtm1Cte/Procrtm1Cte
Tg(Tek-Procr)1Cte/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Procrtm1Cte mutation (0 available); any Procr mutation (17 available)
Tg(Tek-Procr)1Cte mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:119529 )
• embryos are detected at E9.5 but none are observed at E12.5
• treatment of pregnant mice with low-molecular weight heparin prolongs embryo survival to E13.5, but no live births




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory