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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Procrtm1Cte
targeted mutation 1, Charles T Esmon
MGI:2445432
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Procrtm1Cte/Procrtm1Cte either: 129S/SvEv-Procrtm1Cte or (involves: 129S7/SvEvBrd * Black Swiss) MGI:2651883
hm2
 		Procrtm1Cte/Procrtm1Cte involves: 129S7/SvEvBrd MGI:3702948
ht3
 		Procrtm1Cte/Procr+ B6.129S7-Procrtm1Cte MGI:3831372
cn4
 		Meox2tm1(cre)Sor/Meox2+
Procrtm1Cte/Procrtm2Cte 		involves: 129S4/SvJaeSor * 129S7/SvEvBrd * Black Swiss * C57BL/6 MGI:3702950
cx5
 		F3tm1Dco/F3tm1Dco
Procrtm1Cte/Procrtm1Cte 		involves: 129S7/SvEvBrd * BALB/c * Black Swiss * C57BL/6 * FVB/N MGI:3702956
cx6
 		F3tm1Dco/F3tm1Dco
Procrtm1Cte/Procrtm1Cte
Tg(F3)1Nmk/0 		involves: 129S7/SvEvBrd * BALB/c * Black Swiss * C57BL/6 * FVB/N MGI:3702952
cx7
 		Procrtm1Cte/Procrtm1Cte
Tg(F3)1Nmk/0 		involves: 129S7/SvEvBrd * BALB/c * C57BL/6 MGI:3702957
cx8
 		Procrtm1Cte/Procrtm1Cte
Tg(Tek-Procr)1Cte/0 		involves: 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:3703332


Genotype
MGI:2651883
hm1
Allelic
Composition		 Procrtm1Cte/Procrtm1Cte
Genetic
Background		 either: 129S/SvEv-Procrtm1Cte or (involves: 129S7/SvEvBrd * Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Procrtm1Cte mutation (0 available); any Procr mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Procrtm1Cte/Procrtm1Cte embryos are small at E8, growth retarded by E9.5, and do not complete axial rotation

mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:80043 )
• death on or before E10.5
• embryos removed from extraembyronic tissues and cultured in vitro develop beyond E10.5
• anticoagulant treatment fails to fully rescue embryos

embryo
incomplete embryo turning ( J:80043 )
• do not complete axial rotation
• complete axial rotation is observed after anticoagulant treatment
embryonic growth retardation ( J:80043 )
• developmentally growth retarded by E9.5; embryos do not progress past Theiler stage 13
decreased embryo size ( J:80043 )
• smaller in size than wild-type at E8
abnormal extraembryonic tissue morphology ( J:80043 )
• the extra-embryonic membranes are discontinuous at E9.5

growth/size/body
embryonic growth retardation ( J:80043 )
• developmentally growth retarded by E9.5; embryos do not progress past Theiler stage 13
decreased embryo size ( J:80043 )
• smaller in size than wild-type at E8

homeostasis/metabolism
abnormal blood coagulation ( J:80043 )
• fibrin deposition around giant cells, accompanied by infiltration of leukocytes
abnormal placental thrombosis ( J:80043 )
• placental thrombosis




Genotype
MGI:3702948
hm2
Allelic
Composition		 Procrtm1Cte/Procrtm1Cte
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Procrtm1Cte mutation (0 available); any Procr mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:119529 )
• injection of low-molecular weight heparin into pregnant mice from E4.5 to full term partially rescues these pups; 2/48 live born animals are Procrtm1Cte




Genotype
MGI:3831372
ht3
Allelic
Composition		 Procrtm1Cte/Procr+
Genetic
Background		 B6.129S7-Procrtm1Cte
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Procrtm1Cte mutation (0 available); any Procr mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal blood coagulation ( J:144388 )
• activated protein C levels after thrombin infusion are lower than in controls
• slightly reduced fibrinogen levels

hematopoietic system
thrombocytopenia ( J:144388 )
• slightly reduced platelet counts




Genotype
MGI:3702950
cn4
Allelic
Composition		 Meox2tm1(cre)Sor/Meox2+
Procrtm1Cte/Procrtm2Cte
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * Black Swiss * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Procrtm1Cte mutation (0 available); any Procr mutation (15 available)
Procrtm2Cte mutation (0 available); any Procr mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:119529 )
• no Procr-null, Meox2 heterozygous mice are obtained




Genotype
MGI:3702956
cx5
Allelic
Composition		 F3tm1Dco/F3tm1Dco
Procrtm1Cte/Procrtm1Cte
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/c * Black Swiss * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F3tm1Dco mutation (0 available); any F3 mutation (24 available)
Procrtm1Cte mutation (0 available); any Procr mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:119529 )
• no embryos with this genotype are found at birth




Genotype
MGI:3702952
cx6
Allelic
Composition		 F3tm1Dco/F3tm1Dco
Procrtm1Cte/Procrtm1Cte
Tg(F3)1Nmk/0
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/c * Black Swiss * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F3tm1Dco mutation (0 available); any F3 mutation (24 available)
Procrtm1Cte mutation (0 available); any Procr mutation (15 available)
Tg(F3)1Nmk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:119529 )
N
• mice are born at expected frequency and survive at least 8 months




Genotype
MGI:3702957
cx7
Allelic
Composition		 Procrtm1Cte/Procrtm1Cte
Tg(F3)1Nmk/0
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Procrtm1Cte mutation (0 available); any Procr mutation (15 available)
Tg(F3)1Nmk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:119529 )
• no embryos with this genotype are found at birth




Genotype
MGI:3703332
cx8
Allelic
Composition		 Procrtm1Cte/Procrtm1Cte
Tg(Tek-Procr)1Cte/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Procrtm1Cte mutation (0 available); any Procr mutation (15 available)
Tg(Tek-Procr)1Cte mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:119529 )
• embryos are detected at E9.5 but none are observed at E12.5
• treatment of pregnant mice with low-molecular weight heparin prolongs embryo survival to E13.5, but no live births




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory