Phenotypes associated with this allele

• Allele Symbol: Rb1^tm1Jyjw
• Allele Name: targeted mutation 1, Jean YJ Wang
• Allele ID: MGI:2445438
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rb1^tm1Jyjw/Rb1^tm1Jyjw	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)	MGI:2651662
ht2	Rb1^tm1Jyjw/Rb1^+	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)	MGI:3769470

Genotype
MGI:2651662

hm1

• Allelic Composition: Rb1^tm1Jyjw/Rb1^tm1Jyjw
• Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:80087 )

• 5 days after LPS injection, 50% of males recover compared to 33% of wild-type mice

increased susceptibility to induced morbidity/mortality ( J:80087 )

• no mutant females recover (survive) compared to about 33% of wild-type mice or heterozygous females

prenatal lethality, incomplete penetrance ( J:80087 )

• on the 129Sv background a 20% reduction in number of homozygous offspring is noted

behavior/neurological

lethargy ( J:80087 )

• sign of endotoxemia, displayed when animals are treated with LPS

abnormal pilomotor reflex ( J:80087 )

• sign of endotoxemia, displayed when animals are treated with LPS

vision/eye

decreased retina apoptosis ( J:80087 )

• in cultured retina explants, apoptosis in the ganglial cell layer (GCL) resulting from severing of neuronal connections in the retina is reduced compared to wild-type explants

cellular

decreased apoptosis ( J:80087 )

• in response to LPS treatment, apoptosis in the intestine is significantly reduced compared to wild-type mice

decreased retina apoptosis ( J:80087 )

• in cultured retina explants, apoptosis in the ganglial cell layer (GCL) resulting from severing of neuronal connections in the retina is reduced compared to wild-type explants

Genotype
MGI:3769470

ht2

• Allelic Composition: Rb1^tm1Jyjw/Rb1⁺
• Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:80087 )

• 5 days after LPS injection, 58% of males recover compared to 33% of wild-type mice; mutant females show about 25% recovery, not significantly different from wild-type

behavior/neurological

lethargy ( J:80087 )

• sign of endotoxemia, displayed when animals are treated with LPS

abnormal pilomotor reflex ( J:80087 )

• sign of endotoxemia, displayed when animals are treated with LPS

vision/eye

abnormal retina apoptosis ( J:80087 )

• in cultured retina explants, apoptosis in the ganglial cell layer (GCL) is reduced compared to wild-type explants; this protection is transient and somewhat less compared to homozygous mutants

cellular

abnormal retina apoptosis ( J:80087 )

• in cultured retina explants, apoptosis in the ganglial cell layer (GCL) is reduced compared to wild-type explants; this protection is transient and somewhat less compared to homozygous mutants

decreased apoptosis ( J:80087 )

• in response to LPS treatment, apoptosis in the intestine is significantly reduced compared to wild-type mice