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Allele Symbol Allele Name Allele ID |
Rb1tm1.1Jyjw targeted mutation 1.1, Jean YJ Wang MGI:2445439 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 5 days after LPS injection, 50% of males recover compared to 33% of wild-type mice
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• no mutant females recover (survive) compared to about 33% of wild-type mice or heterozygous females
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• on the 129Sv background a 20% reduction in number of homozygous offspring is noted
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• sign of endotoxemia, displayed when animals are treated with LPS
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• in cultured retina explants, apoptosis in the ganglial cell layer (GCL) resulting from severing of neuronal connections in the retina is reduced compared to wild-type explants
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• in cultured retina explants, apoptosis in the ganglial cell layer (GCL) resulting from severing of neuronal connections in the retina is reduced compared to wild-type explants
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• in response to LPS treatment, apoptosis in the intestine is significantly reduced compared to wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 5 days after LPS injection, 58% of males recover compared to 33% of wild-type mice; mutant females show about 25% recovery, not significantly different from wild-type
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• sign of endotoxemia, displayed when animals are treated with LPS
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• in cultured retina explants, apoptosis in the ganglial cell layer (GCL) is reduced compared to wild-type explants; this protection is transient and somewhat less compared to homozygous mutants
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• in response to LPS treatment, apoptosis in the intestine is significantly reduced compared to wild-type mice
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• in cultured retina explants, apoptosis in the ganglial cell layer (GCL) is reduced compared to wild-type explants; this protection is transient and somewhat less compared to homozygous mutants
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice become moribund from lymphoma involving various tissues within >30 weeks; mice with aggressive lymphoma have a mean survival time of 18 weeks
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• after 7 days of DSS treatment, size of induced ulcers is significantly lower than in Trp53 single mutant littermates
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• there is a significantly higher incidence of colon tumors in moribund mice with disseminated lymphoma than in Trp53-null single mutant littermates
• tumors have mixture of inflammatory infiltrates within the tumor areas and luminal surface have disrupted epithelial barrier, while colonic tumors
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• aggressive adenocarcinoma of the colon is observed in double mutants whereas only 1 Trp53 single mutant developed that tumor type; tumors extend through the muscularis mucosa, submucosa, and muscularis, reaching the pericolonic fat
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• there is a significantly higher incidence of colon tumors in moribund mice with disseminated lymphoma than in Trp53-null single mutant littermates
• tumors have mixture of inflammatory infiltrates within the tumor areas and luminal surface have disrupted epithelial barrier, while colonic tumors
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• aggressive adenocarcinoma of the colon is observed in double mutants whereas only 1 Trp53 single mutant developed that tumor type; tumors extend through the muscularis mucosa, submucosa, and muscularis, reaching the pericolonic fat
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• mice develop lymphomas, with ~same time of onset and same survival time as Trp53-single mutants
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• median survival time of mice with teratomas is 7 weeks compared to 10 weeks for Rb1-sufficient, Trp53-null mice
• higher percentage of teratomas show necrosis with hemorrhage, and are more frequently associated with metastasis than teratomas in Trp53-null single mutant littermates
• ~30% of mice surviving beyond median survival age show extratesticular teratomas in lung, liver, lymph nodes, and/or pancreas
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• incidence of testicular tumors is higher than in Trp53 single mutant littermates
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• apoptosis of colonic epithelium is lower in double mutants than in Trp53-nulls after treatment with dextran sodium sulfate (DSS) to induce colonic injury
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• with DSS treatment, double mutants have a reduced average weight loss (loss of 9% body weight) compared to Trp53 single mutants (loss of 14% body weight)
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• incidence of testicular tumors is higher than in Trp53 single mutant littermates
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• incidence of testicular tumors is higher than in Trp53 single mutant littermates
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/05/2024 MGI 6.24 |
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