Phenotypes associated with this allele

• Allele Symbol: Tg(GFAP-TAg121)1Tvd
• Allele Name: transgene insertion 1, Terry Van Dyke
• Allele ID: MGI:2445447
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pten^tm2.1Ppp/Pten^tm2.1Ppp Tg(GFAP-TAg121)1Tvd/0	involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2 * FVB/N	MGI:5286094
tg2	Tg(GFAP-TAg121)1Tvd/0	involves: C57BL/6 * DBA/2 * FVB/N	MGI:5286087

Genotype
MGI:5286094

cn1

• Allelic Composition: Pten^tm2.1Ppp/Pten^tm2.1Ppp; Tg(GFAP-TAg121)1Tvd/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain vasculature morphology ( J:99385 )

• mice infected with a cre-expression virus exhibit increased angiogenesis in the cerebral cortex compared to in control mice

abnormal astrocyte apoptosis ( J:99385 )

• mice infected with a cre-expression virus exhibit astrocytmoa with increased invasiveness compared with mice expressing Tg(GFAP-TAg121)1Tvd

increased astrocytoma incidence ( J:99385 )

• mice infected with a cre-expression virus exhibit astrocytmoa with increased invasiveness compared with mice expressing Tg(GFAP-TAg121)1Tvd

neoplasm

increased astrocytoma incidence ( J:99385 )

• mice infected with a cre-expression virus exhibit astrocytmoa with increased invasiveness compared with mice expressing Tg(GFAP-TAg121)1Tvd

cardiovascular system

abnormal brain vasculature morphology ( J:99385 )

• mice infected with a cre-expression virus exhibit increased angiogenesis in the cerebral cortex compared to in control mice

increased angiogenesis ( J:99385 )

• in cerebral cortex injected with cre-expressing virus

cellular

abnormal astrocyte apoptosis ( J:99385 )

• mice infected with a cre-expression virus exhibit astrocytmoa with increased invasiveness compared with mice expressing Tg(GFAP-TAg121)1Tvd

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
malignant astrocytoma		DOID:3069		J:99385

Genotype
MGI:5286087

tg2

• Allelic Composition: Tg(GFAP-TAg121)1Tvd/0
• Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

mortality/aging

premature death ( J:77132 )

• mice die at 5 to 8 months of age

nervous system

increased astrocytoma incidence ( J:77132 )

• malignant anaplastic

abnormal brain morphology ( J:77132 )

• at P7, mice exhibit increased periventriular cellularity compared with control mice but not as severe as in Tg(GFAP-SV40T)1Tvd mice

neoplasm

increased astrocytoma incidence ( J:77132 )

• malignant anaplastic

growth/size/body

weight loss ( J:77132 )

• at 1 to 3 months of age

craniofacial

abnormal cranium morphology ( J:77132 )

• bulging cranial at 1 to 3 months of age

skeleton

abnormal cranium morphology ( J:77132 )

• bulging cranial at 1 to 3 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
malignant astrocytoma		DOID:3069		J:77132