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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Socs1tm1Kish
targeted mutation 1, Tadamitsu Kishimoto
MGI:2445448
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Socs1tm1Kish/Socs1tm1Kish B6.129P2-Socs1tm1Kish MGI:3771362
hm2
 		Socs1tm1Kish/Socs1tm1Kish involves: 129P2/OlaHsd * C57BL/6J MGI:2652622
cx3
 		Socs1tm1Kish/Socs1tm1Kish
Stat1tm1Rds/Stat1tm1Rds 		involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:3771360
cx4
 		Socs1tm1Kish/Socs1tm1Kish
Stat6tm1Aki/Stat6tm1Aki 		involves: 129P2/OlaHsd * C57BL/6 MGI:3771361


Genotype
MGI:3771362
hm1
Allelic
Composition		 Socs1tm1Kish/Socs1tm1Kish
Genetic
Background		 B6.129P2-Socs1tm1Kish
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs1tm1Kish mutation (0 available); any Socs1 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:69472 )
• all mice die within 3 weeks after birth

immune system
increased NK T cell number ( J:69472 )
• interferon-gamma stimulation leads to increased numbers of NK T cells compared to in wild-type mice
abnormal lymphocyte physiology ( J:69472 )
• when transplanted into Rag2 null mice, abnormal lymphocytes cause similar defects as observed in Socs1tm1Kish homozygotes
• mice exhibit hepatocytoxicity but depletion of NK1.1 cells reduces toxicity
liver inflammation ( J:69472 )
• mice exhibit fulminant hepatitis characterized by severe fatty degeneration and necrosis with massive lymphocyte infiltration
• unlike in wild-type mice, treatment with alpha-galactoceramide induces fulminant hepatitis within 12 hours

liver/biliary system
liver inflammation ( J:69472 )
• mice exhibit fulminant hepatitis characterized by severe fatty degeneration and necrosis with massive lymphocyte infiltration
• unlike in wild-type mice, treatment with alpha-galactoceramide induces fulminant hepatitis within 12 hours

homeostasis/metabolism
increased susceptibility to injury ( J:69472 )
• treatment with interferon-gamma and IL-4, but not either alone, induces severe liver injury in pre-onset mice

growth/size/body
decreased body size ( J:69472 )
enlarged liver ( J:69472 )

hematopoietic system
increased NK T cell number ( J:69472 )
• interferon-gamma stimulation leads to increased numbers of NK T cells compared to in wild-type mice
abnormal lymphocyte physiology ( J:69472 )
• when transplanted into Rag2 null mice, abnormal lymphocytes cause similar defects as observed in Socs1tm1Kish homozygotes
• mice exhibit hepatocytoxicity but depletion of NK1.1 cells reduces toxicity

endocrine/exocrine glands




Genotype
MGI:2652622
hm2
Allelic
Composition		 Socs1tm1Kish/Socs1tm1Kish
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs1tm1Kish mutation (0 available); any Socs1 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Histological appearances of the spleen and thymus in Socs1tm1Kish/Socs1tm1Kish mice

mortality/aging
postnatal lethality, complete penetrance ( J:51685 )
• death by 3 weeks of age

growth/size/body
postnatal growth retardation ( J:51685 )
enlarged liver ( J:51685 )
• hepatomegaly

immune system
absent thymus corticomedullary boundary ( J:51685 )
• no border between cortex and medulla
decreased lymphocyte cell number ( J:51685 )
• decreased lymphocyte numbers, but normal differentiation, in the spleen and thymus at postnatal day 10
• increased lymphocyte apoptosis in spleen and thymus
abnormal spleen morphology ( J:51685 )
• distorted shape
abnormal spleen white pulp morphology ( J:51685 )
• atrophy of white pulp

liver/biliary system
enlarged liver ( J:51685 )
• hepatomegaly

hematopoietic system
absent thymus corticomedullary boundary ( J:51685 )
• no border between cortex and medulla
decreased lymphocyte cell number ( J:51685 )
• decreased lymphocyte numbers, but normal differentiation, in the spleen and thymus at postnatal day 10
• increased lymphocyte apoptosis in spleen and thymus
abnormal spleen morphology ( J:51685 )
• distorted shape
abnormal spleen white pulp morphology ( J:51685 )
• atrophy of white pulp

endocrine/exocrine glands
absent thymus corticomedullary boundary ( J:51685 )
• no border between cortex and medulla




Genotype
MGI:3771360
cx3
Allelic
Composition		 Socs1tm1Kish/Socs1tm1Kish
Stat1tm1Rds/Stat1tm1Rds
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs1tm1Kish mutation (0 available); any Socs1 mutation (30 available)
Stat1tm1Rds mutation (4 available); any Stat1 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:69472 )
• mice survive past weaning but exhibit premature death compared to wild-type mice

immune system
immune system phenotype ( J:69472 )
N
• unlike in Socs1tm1Kish homozygotes, interferon-gamma stimulation does not lead to increased numbers of NK T cells
thymus atrophy ( J:69472 )
• thymic atrophy observed in Socs1tm1Kish homozygotes is partially rescued
increased activated T cell number ( J:69472 )
• while mice produce less activated T cells than Socs1tm1Kish homozygotes, the number of activated T cells is still larger than in wild-type mice
liver inflammation ( J:69472 )
• unlike in Socs1tm1Kish homozygotes, only a small number of lymphocytes infiltrate the liver

liver/biliary system
enlarged liver ( J:69472 )
• hepatomegaly observed in Socs1tm1Kish homozygotes is almost completely rescued
liver inflammation ( J:69472 )
• unlike in Socs1tm1Kish homozygotes, only a small number of lymphocytes infiltrate the liver

growth/size/body
decreased body size ( J:69472 )
• mice are larger than Socs1tm1Kish homozygotes but smaller than wild-type mice
postnatal growth retardation ( J:69472 )
enlarged liver ( J:69472 )
• hepatomegaly observed in Socs1tm1Kish homozygotes is almost completely rescued

hematopoietic system
thymus atrophy ( J:69472 )
• thymic atrophy observed in Socs1tm1Kish homozygotes is partially rescued
increased activated T cell number ( J:69472 )
• while mice produce less activated T cells than Socs1tm1Kish homozygotes, the number of activated T cells is still larger than in wild-type mice

endocrine/exocrine glands
thymus atrophy ( J:69472 )
• thymic atrophy observed in Socs1tm1Kish homozygotes is partially rescued




Genotype
MGI:3771361
cx4
Allelic
Composition		 Socs1tm1Kish/Socs1tm1Kish
Stat6tm1Aki/Stat6tm1Aki
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs1tm1Kish mutation (0 available); any Socs1 mutation (30 available)
Stat6tm1Aki mutation (7 available); any Stat6 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:69472 )
• mice survive past weaning but exhibit premature death compared to wild-type mice

immune system
immune system phenotype ( J:69472 )
N
• unlike in Socs1tm1Kish homozygotes, interferon-gamma stimulation does not lead to increased numbers of NK T cells
thymus atrophy ( J:69472 )
• thymic atrophy observed in Socs1tm1Kish homozygotes is partially rescued
increased activated T cell number ( J:69472 )
• while mice produce less activated T cells than Socs1tm1Kish homozygotes, the number of activated T cells is still larger than in wild-type mice
liver inflammation ( J:69472 )
• unlike in Socs1tm1Kish homozygotes, only a small number of lymphocytes infiltrate the liver

liver/biliary system
enlarged liver ( J:69472 )
• hepatomegaly observed in Socs1tm1Kish homozygotes is almost completely rescued
liver inflammation ( J:69472 )
• unlike in Socs1tm1Kish homozygotes, only a small number of lymphocytes infiltrate the liver

growth/size/body
decreased body size ( J:69472 )
• mice are larger than Socs1tm1Kish homozygotes but smaller than wild-type mice
postnatal growth retardation ( J:69472 )
enlarged liver ( J:69472 )
• hepatomegaly observed in Socs1tm1Kish homozygotes is almost completely rescued

hematopoietic system
thymus atrophy ( J:69472 )
• thymic atrophy observed in Socs1tm1Kish homozygotes is partially rescued
increased activated T cell number ( J:69472 )
• while mice produce less activated T cells than Socs1tm1Kish homozygotes, the number of activated T cells is still larger than in wild-type mice

endocrine/exocrine glands
thymus atrophy ( J:69472 )
• thymic atrophy observed in Socs1tm1Kish homozygotes is partially rescued




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory