Phenotypes associated with this allele

• Allele Symbol: Suv39h1^tm1Jnw
• Allele Name: targeted mutation 1, Thomas Jenuwein
• Allele ID: MGI:2445449
• Summary: 7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Suv39h1^tm1Jnw/Suv39h1^tm1Jnw	involves: 129	MGI:5438249
hm2	Suv39h1^tm1Jnw/Suv39h1^tm1Jnw	involves: 129 * C57BL/6J	MGI:3033495
ht3	Suv39h1^tm1Jnw/Suv39h1^+	involves: 129 * C57BL/6J	MGI:3033494
cx4	Suv39h1^tm1Jnw/Suv39h1^tm1Jnw Suv39h2^tm1Jnw/Suv39h2^tm1Jnw	involves: 129 * C57BL/6J	MGI:3033496
cx5	Suv39h1^tm1Jnw/Suv39h1^tm1Jnw Suv39h2^tm1Jnw/Suv39h2^+	involves: 129 * C57BL/6J	MGI:3033497
cx6	Suv39h1^tm1Jnw/Suv39h1^+ Suv39h2^tm1Jnw/Suv39h2^+	involves: 129 * C57BL/6J	MGI:3033498
cx7	Suv39h1^tm1Jnw/Suv39h1^+ Suv39h2^tm1Jnw/Suv39h2^tm1Jnw	involves: 129 * C57BL/6J	MGI:3033499

Genotype
MGI:5438249

hm1

• Allelic Composition: Suv39h1^tm1Jnw/Suv39h1^tm1Jnw
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T-helper 2 physiology ( J:186702 )

• TH2 cells exhibit increased plasticity under TH1 promoting conditions compared with wild-type cells

• TH2 stability in vivo is impaired compared with wild-type cells

decreased susceptibility to type I hypersensitivity reaction ( J:186702 )

• ovalbumin-exposed mice exhibit reduced allergic lung inflammation compared with wild-type mice

hematopoietic system

abnormal T-helper 2 physiology ( J:186702 )

• TH2 cells exhibit increased plasticity under TH1 promoting conditions compared with wild-type cells

• TH2 stability in vivo is impaired compared with wild-type cells

Genotype
MGI:3033495

hm2

• Allelic Composition: Suv39h1^tm1Jnw/Suv39h1^tm1Jnw
• Genetic Background: involves: 129 * C57BL/6J

neoplasm

increased B cell derived lymphoma incidence ( J:72503 )

♀ • B cell lymphomas developed in 30% of mice compared to controls

Genotype
MGI:3033494

ht3

• Allelic Composition: Suv39h1^tm1Jnw/Suv39h1⁺
• Genetic Background: involves: 129 * C57BL/6J

neoplasm

increased B cell derived lymphoma incidence ( J:72503 )

♀ • B cell lymphomas developed in 30% of mice compared to controls

Genotype
MGI:3033496

cx4

• Allelic Composition: Suv39h1^tm1Jnw/Suv39h1^tm1Jnw; Suv39h2^tm1Jnw/Suv39h2^tm1Jnw
• Genetic Background: involves: 129 * C57BL/6J

mortality/aging

prenatal lethality, incomplete penetrance ( J:72503 )

♀ • incomplete penetrance; more than half of double homozyous animals die before birth

embryo

decreased embryo size ( J:72503 )

♀ • double homozygous embryos are smaller than controls

growth/size/body

decreased embryo size ( J:72503 )

♀ • double homozygous embryos are smaller than controls

postnatal growth retardation ( J:72503 )

♀

reproductive system

arrest of male meiosis ( J:72503 )

♂ • spermatogenesis in impaired with an arrest of differentiation at the transition stage between early and late spermatocytes; an accumulation of preleptotene spermatocytes and the appearance of apoptotic mid to late pachytene spermatocytes with meiotic defects were noted

small gonad ( J:72503 )

♀ • male hypogonadism was noted in mice surviving past birth

infertility ( J:72503 )

♀

cellular

arrest of male meiosis ( J:72503 )

♂ • spermatogenesis in impaired with an arrest of differentiation at the transition stage between early and late spermatocytes; an accumulation of preleptotene spermatocytes and the appearance of apoptotic mid to late pachytene spermatocytes with meiotic defects were noted

Genotype
MGI:3033497

cx5

• Allelic Composition: Suv39h1^tm1Jnw/Suv39h1^tm1Jnw; Suv39h2^tm1Jnw/Suv39h2⁺
• Genetic Background: involves: 129 * C57BL/6J

neoplasm

increased B cell derived lymphoma incidence ( J:72503 )

♀ • B cell lymphomas developed in 28% of mice compared to controls

Genotype
MGI:3033498

cx6

• Allelic Composition: Suv39h1^tm1Jnw/Suv39h1⁺; Suv39h2^tm1Jnw/Suv39h2⁺
• Genetic Background: involves: 129 * C57BL/6J

neoplasm

increased B cell derived lymphoma incidence ( J:72503 )

♀ • B cell lymphomas developed in 28% of mice compared to controls

Genotype
MGI:3033499

cx7

• Allelic Composition: Suv39h1^tm1Jnw/Suv39h1⁺; Suv39h2^tm1Jnw/Suv39h2^tm1Jnw
• Genetic Background: involves: 129 * C57BL/6J

neoplasm

increased B cell derived lymphoma incidence ( J:72503 )

♀ • B cell lymphomas developed in less than 5% of mice compared to controls