About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Suv39h2tm1Jnw
targeted mutation 1, Thomas Jenuwein
MGI:2445450
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Suv39h2tm1Jnw/Suv39h2tm1Jnw involves: 129 * C57BL/6J MGI:3033492
ht2
 		Suv39h2tm1Jnw/Suv39h2+ involves: 129 * C57BL/6J MGI:3033493
cx3
 		Suv39h1tm1Jnw/Suv39h1tm1Jnw
Suv39h2tm1Jnw/Suv39h2tm1Jnw 		involves: 129 * C57BL/6J MGI:3033496
cx4
 		Suv39h1tm1Jnw/Suv39h1tm1Jnw
Suv39h2tm1Jnw/Suv39h2+ 		involves: 129 * C57BL/6J MGI:3033497
cx5
 		Suv39h1tm1Jnw/Suv39h1+
Suv39h2tm1Jnw/Suv39h2+ 		involves: 129 * C57BL/6J MGI:3033498
cx6
 		Suv39h1tm1Jnw/Suv39h1+
Suv39h2tm1Jnw/Suv39h2tm1Jnw 		involves: 129 * C57BL/6J MGI:3033499


Genotype
MGI:3033492
hm1
Allelic
Composition		 Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suv39h2tm1Jnw mutation (0 available); any Suv39h2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased B cell derived lymphoma incidence ( J:72503 )
• B cell lymphomas developed in less than 5% of mice compared to controls




Genotype
MGI:3033493
ht2
Allelic
Composition		 Suv39h2tm1Jnw/Suv39h2+
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suv39h2tm1Jnw mutation (0 available); any Suv39h2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased B cell derived lymphoma incidence ( J:72503 )
• B cell lymphomas developed in less than 5% of mice compared to controls




Genotype
MGI:3033496
cx3
Allelic
Composition		 Suv39h1tm1Jnw/Suv39h1tm1Jnw
Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suv39h1tm1Jnw mutation (0 available); any Suv39h1 mutation (10 available)
Suv39h2tm1Jnw mutation (0 available); any Suv39h2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:72503 )
• incomplete penetrance; more than half of double homozyous animals die before birth

embryo
decreased embryo size ( J:72503 )
• double homozygous embryos are smaller than controls

growth/size/body
decreased embryo size ( J:72503 )
• double homozygous embryos are smaller than controls
postnatal growth retardation ( J:72503 )

reproductive system
arrest of male meiosis ( J:72503 )
• spermatogenesis in impaired with an arrest of differentiation at the transition stage between early and late spermatocytes; an accumulation of preleptotene spermatocytes and the appearance of apoptotic mid to late pachytene spermatocytes with meiotic defects were noted
small gonad ( J:72503 )
• male hypogonadism was noted in mice surviving past birth

cellular
arrest of male meiosis ( J:72503 )
• spermatogenesis in impaired with an arrest of differentiation at the transition stage between early and late spermatocytes; an accumulation of preleptotene spermatocytes and the appearance of apoptotic mid to late pachytene spermatocytes with meiotic defects were noted




Genotype
MGI:3033497
cx4
Allelic
Composition		 Suv39h1tm1Jnw/Suv39h1tm1Jnw
Suv39h2tm1Jnw/Suv39h2+
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suv39h1tm1Jnw mutation (0 available); any Suv39h1 mutation (10 available)
Suv39h2tm1Jnw mutation (0 available); any Suv39h2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased B cell derived lymphoma incidence ( J:72503 )
• B cell lymphomas developed in 28% of mice compared to controls




Genotype
MGI:3033498
cx5
Allelic
Composition		 Suv39h1tm1Jnw/Suv39h1+
Suv39h2tm1Jnw/Suv39h2+
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suv39h1tm1Jnw mutation (0 available); any Suv39h1 mutation (10 available)
Suv39h2tm1Jnw mutation (0 available); any Suv39h2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased B cell derived lymphoma incidence ( J:72503 )
• B cell lymphomas developed in 28% of mice compared to controls




Genotype
MGI:3033499
cx6
Allelic
Composition		 Suv39h1tm1Jnw/Suv39h1+
Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suv39h1tm1Jnw mutation (0 available); any Suv39h1 mutation (10 available)
Suv39h2tm1Jnw mutation (0 available); any Suv39h2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased B cell derived lymphoma incidence ( J:72503 )
• B cell lymphomas developed in less than 5% of mice compared to controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory