neoplasm
• B cell lymphomas developed in less than 5% of mice compared to controls
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Allele Symbol Allele Name Allele ID |
Suv39h2tm1Jnw targeted mutation 1, Thomas Jenuwein MGI:2445450 |
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Summary |
6 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• B cell lymphomas developed in less than 5% of mice compared to controls
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• B cell lymphomas developed in less than 5% of mice compared to controls
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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• incomplete penetrance; more than half of double homozyous animals die before birth
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• double homozygous embryos are smaller than controls
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• double homozygous embryos are smaller than controls
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• spermatogenesis in impaired with an arrest of differentiation at the transition stage between early and late spermatocytes; an accumulation of preleptotene spermatocytes and the appearance of apoptotic mid to late pachytene spermatocytes with meiotic defects were noted
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• male hypogonadism was noted in mice surviving past birth
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• spermatogenesis in impaired with an arrest of differentiation at the transition stage between early and late spermatocytes; an accumulation of preleptotene spermatocytes and the appearance of apoptotic mid to late pachytene spermatocytes with meiotic defects were noted
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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• B cell lymphomas developed in 28% of mice compared to controls
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|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
|
• B cell lymphomas developed in 28% of mice compared to controls
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
|
• B cell lymphomas developed in less than 5% of mice compared to controls
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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