Phenotypes associated with this allele

• Allele Symbol: Polk^tm1.1Rsky
• Allele Name: targeted mutation 1.1, Klaus Rajewsky
• Allele ID: MGI:2445458
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Polk^tm1.1Rsky/Polk^tm1.1Rsky	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6	MGI:3790675

Genotype
MGI:3790675

hm1

• Allelic Composition: Polk^tm1.1Rsky/Polk^tm1.1Rsky
• Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased cellular sensitivity to ultraviolet irradiation ( J:80212 )

• murine embryonic fibroblasts are more sensitive to UV radiation than wild-type cells; sensitivity is same as that of Xpc^tm1Ecf homozygous cells

abnormal DNA repair ( J:112191 )

• male mutants display higher rate of spontaneous germline expanded simple tandem repeat (ESTR) mutations (2-fold) relative to isogenic BALB/cJ wild-type males

immune system

immune system phenotype ( J:80212 )

N • mutants have normal B and T cell populations in blood and spleen

N • humoral immune response to a T-cell dependent antigen is normal

N • germinal center B cells show normal somatic hypermutation

homeostasis/metabolism

abnormal DNA repair ( J:112191 )

• male mutants display higher rate of spontaneous germline expanded simple tandem repeat (ESTR) mutations (2-fold) relative to isogenic BALB/cJ wild-type males