All Phenotypes Xist<tm2.1Jae> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Xist^tm2.1Jae
targeted mutation 2.1, Rudolf Jaenisch
MGI:2445460

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Xist^tm2.1Jae/Xist⁺	involves: 129	MGI:3719989
ht2	Xist^tm1Jae/Xist^tm2.1Jae	involves: 129S4/SvJae	MGI:3772897
ot3	Xist^tm2.1Jae/Y	Not Specified	MGI:3719991

Allelic Composition	Xist^tm2.1Jae/Xist⁺
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xist^tm2.1Jae mutation (0 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal dosage compensation, by inactivation of X chromosome ( J:95871 )

• E7.0 embryos exhibit selective inactivation of the wild-type allele instead of the random inactivation observed in wild-type embryos

embryo

embryonic growth retardation ( J:174672 )

• when the allele is inherited paternally, female mice exhibit severe developmental defect at E7.5 compared with control mice

growth/size/body

embryonic growth retardation ( J:174672 )

• when the allele is inherited paternally, female mice exhibit severe developmental defect at E7.5 compared with control mice

Allelic Composition	Xist^tm1Jae/Xist^tm2.1Jae
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xist^tm1Jae mutation (0 available); any Xist mutation (8 available)
Xist^tm2.1Jae mutation (0 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:75502 )

• mouse embryonic fibroblasts exhibit normal X chromosome inactivation

Allelic Composition	Xist^tm2.1Jae/Y
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xist^tm2.1Jae mutation (0 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:80117 )

N	• formation of sex bodies and meiotic sex chromosome inactivation in spermatocytes is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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