All Phenotypes Ikbkb<tm2Mka> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ikbkb^tm2Mka
targeted mutation 2, Michael Karin
MGI:2445462

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ikbkb^tm2Mka/Ikbkb^tm2.1Mka Tg(Vil-cre)1Mka/0	involves: 129	MGI:3038976
cn2	Ikbkb^tm2Mka/Ikbkb^tm2Mka Tg(Ckmm-cre)1Lrsn/0	involves: 129	MGI:3799267
cn3	Ikbkb^tm2Mka/Ikbkb^tm2Mka Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129/Sv * 129P2/OlaHsd	MGI:4843279
cn4	Cd19^tm1(cre)Cgn/Cd19⁺ Ikbkb^tm2Mka/Ikbkb^tm2Mka	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:2657004
cn5	Ikbkb^tm2Mka/Ikbkb^tm2.1Mka Tg(Vil-cre)1Mka/0	involves: 129/Sv * C57BL/6	MGI:2662291

Allelic Composition	Ikbkb^tm2Mka/Ikbkb^tm2.1Mka Tg(Vil-cre)1Mka/0
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkb^tm2.1Mka mutation (0 available); any Ikbkb mutation (56 available)
Ikbkb^tm2Mka mutation (0 available); any Ikbkb mutation (56 available)
Tg(Vil-cre)1Mka mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased cellular sensitivity to gamma-irradiation ( J:88644 )

• small intestinal crypt epithelial cells are more sensitive to gamma-radiation, showing an increase in apoptosis after irradiation

increased enterocyte apoptosis ( J:88644 )

• LPS injection alone induces apoptosis in intestinal epithelial cells of mutants but not controls

• small intestinal crypt epithelial cells exhibit an increase in apoptosis after gamma-irradiation

• LPS injection before ionizing radiation significantly increases the number of apoptotic intestinal epithelial cells in mutants by about 70%

digestive/alimentary system

increased enterocyte apoptosis ( J:88644 )

• LPS injection alone induces apoptosis in intestinal epithelial cells of mutants but not controls

• small intestinal crypt epithelial cells exhibit an increase in apoptosis after gamma-irradiation

• LPS injection before ionizing radiation significantly increases the number of apoptotic intestinal epithelial cells in mutants by about 70%

Allelic Composition	Ikbkb^tm2Mka/Ikbkb^tm2Mka Tg(Ckmm-cre)1Lrsn/0
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkb^tm2Mka mutation (0 available); any Ikbkb mutation (56 available)
Tg(Ckmm-cre)1Lrsn mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal myotube morphology ( J:135692 )

• under long-term differentiation conditions without medium replenishment, myotubes are 48% less atrophic compared to similarly treated wild-type mouse embryonic fibroblasts

increased skeletal muscle fiber number ( J:135692 )

• the number of intermediate fibers is increased compared to in wild-type mice

Allelic Composition	Ikbkb^tm2Mka/Ikbkb^tm2Mka Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkb^tm2Mka mutation (0 available); any Ikbkb mutation (56 available)
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased macrophage apoptosis ( J:80159 )

• bone marrow-derived macrophages exhibit LPS-induced apoptosis unlike control cells

cellular

increased macrophage apoptosis ( J:80159 )

• bone marrow-derived macrophages exhibit LPS-induced apoptosis unlike control cells

hematopoietic system

increased macrophage apoptosis ( J:80159 )

• bone marrow-derived macrophages exhibit LPS-induced apoptosis unlike control cells

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Ikbkb^tm2Mka/Ikbkb^tm2Mka
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Ikbkb^tm2Mka mutation (0 available); any Ikbkb mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased B cell apoptosis ( J:82995 )

• decrease in survival of B cells

decreased B cell number ( J:82995 )

• reduction in populations of some peripheral B cell subsets, particularly the lymph node compartment

• B cell generation is not impaired

decreased B-1 B cell number ( J:82995 )

• reduced number of peritoneal B-1 cells

decreased marginal zone B cell number ( J:82995 )

abnormal B cell activation ( J:82995 )

• mutants fail to mount effective antibody responses to T cell-dependent and independent antigens

decreased B cell proliferation ( J:82995 )

• hypoproliferation in response to anti-IgM, LPS, and anti-Tnfrsf5 (anti9-CD40)

decreased IgG level ( J:82995 )

• decrease in basal IgG levels

decreased IgM level ( J:82995 )

• decrease in basal IgM levels

immune system

increased B cell apoptosis ( J:82995 )

• decrease in survival of B cells

decreased B cell number ( J:82995 )

• reduction in populations of some peripheral B cell subsets, particularly the lymph node compartment

• B cell generation is not impaired

decreased B-1 B cell number ( J:82995 )

• reduced number of peritoneal B-1 cells

decreased marginal zone B cell number ( J:82995 )

abnormal B cell activation ( J:82995 )

• mutants fail to mount effective antibody responses to T cell-dependent and independent antigens

decreased B cell proliferation ( J:82995 )

• hypoproliferation in response to anti-IgM, LPS, and anti-Tnfrsf5 (anti9-CD40)

decreased IgG level ( J:82995 )

• decrease in basal IgG levels

decreased IgM level ( J:82995 )

• decrease in basal IgM levels

cellular

increased B cell apoptosis ( J:82995 )

• decrease in survival of B cells

decreased B cell proliferation ( J:82995 )

• hypoproliferation in response to anti-IgM, LPS, and anti-Tnfrsf5 (anti9-CD40)

Allelic Composition	Ikbkb^tm2Mka/Ikbkb^tm2.1Mka Tg(Vil-cre)1Mka/0
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal intestinal mucosa morphology ( J:83313 )

• loss of mucosal integrity and increased number of apoptotic cells after gut ischemia-reperfusion

intestinal edema ( J:83313 )

• mutants develop severe intestinal edematous change in response to gut ischemia-reperfusion compared to only mild edema in controls

immune system

impaired neutrophil recruitment ( J:83313 )

• neutrophil migration/recruitment into the lung after gut ischemia-reperfusion is reduced and lung edema is prevented

decreased circulating tumor necrosis factor level ( J:83313 )

• the increase in serum TNF-alpha that is observed in controls at 4 hours after gut ischemia-reperfusion is abolished

decreased acute inflammation ( J:83313 )

• reduction in systemic inflammatory response following gut ischemia-reperfusion

homeostasis/metabolism

intestinal edema ( J:83313 )

• mutants develop severe intestinal edematous change in response to gut ischemia-reperfusion compared to only mild edema in controls

decreased circulating tumor necrosis factor level ( J:83313 )

• the increase in serum TNF-alpha that is observed in controls at 4 hours after gut ischemia-reperfusion is abolished

abnormal response to injury ( J:83313 )

• mutants show increased local injury but prevention of systemic inflammation following intestinal ischemia-reperfusion

hematopoietic system

impaired neutrophil recruitment ( J:83313 )

• neutrophil migration/recruitment into the lung after gut ischemia-reperfusion is reduced and lung edema is prevented

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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