All Phenotypes Gja1<tm1.1Kwi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gja1^tm1.1Kwi
targeted mutation 1., Klaus Willecke
MGI:2445472

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gja1^tm1.1Kwi/Gja1^tm1.1Kwi	involves: 129P2/OlaHsd	MGI:3621034
ht2	Gja1^tm1.1Kwi/Gja1⁺	involves: 129P2/OlaHsd	MGI:3769010
ht3	Gja1^tm1.1Kwi/Gja1^tm4Kwi	involves: 129P2/OlaHsd * C57BL/6	MGI:3525604
ht4	Gja1^tm1Kdr/Gja1^tm1.1Kwi	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J	MGI:3621037

Allelic Composition	Gja1^tm1.1Kwi/Gja1^tm1.1Kwi
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja1^tm1.1Kwi mutation (0 available); any Gja1 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:78662 )

• homozygotes die within 1 day after birth

Allelic Composition	Gja1^tm1.1Kwi/Gja1⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja1^tm1.1Kwi mutation (0 available); any Gja1 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal neutrophil physiology ( J:129091 )

• ATP release from polymorphonuclear (PMN) cells is lower than in wild-type PMNs but higher than in null mice

hematopoietic system

abnormal neutrophil physiology ( J:129091 )

• ATP release from polymorphonuclear (PMN) cells is lower than in wild-type PMNs but higher than in null mice

Allelic Composition	Gja1^tm1.1Kwi/Gja1^tm4Kwi
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja1^tm1.1Kwi mutation (0 available); any Gja1 mutation (59 available)
Gja1^tm4Kwi mutation (1 available); any Gja1 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:95050 )

• about 50% of compound heterozygotes survive to adulthood

integument

integument phenotype ( J:95050 )

N	• skin appearance and barrier function are normal

Allelic Composition	Gja1^tm1Kdr/Gja1^tm1.1Kwi
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja1^tm1.1Kwi mutation (0 available); any Gja1 mutation (59 available)
Gja1^tm1Kdr mutation (1 available); any Gja1 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:78662 )

• homozygotes die within 1 day after birth

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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