mortality/aging
• homozygotes die within 1 day after birth
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Allele Symbol Allele Name Allele ID |
Gja1tm1.1Kwi targeted mutation 1., Klaus Willecke MGI:2445472 |
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Summary |
4 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• homozygotes die within 1 day after birth
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• ATP release from polymorphonuclear (PMN) cells is lower than in wild-type PMNs but higher than in null mice
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• ATP release from polymorphonuclear (PMN) cells is lower than in wild-type PMNs but higher than in null mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• about 50% of compound heterozygotes survive to adulthood
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N |
• skin appearance and barrier function are normal
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• homozygotes die within 1 day after birth
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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