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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gja1tm1.1Kwi
targeted mutation 1., Klaus Willecke
MGI:2445472
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gja1tm1.1Kwi/Gja1tm1.1Kwi involves: 129P2/OlaHsd MGI:3621034
ht2
 		Gja1tm1.1Kwi/Gja1+ involves: 129P2/OlaHsd MGI:3769010
ht3
 		Gja1tm1.1Kwi/Gja1tm4Kwi involves: 129P2/OlaHsd * C57BL/6 MGI:3525604
ht4
 		Gja1tm1Kdr/Gja1tm1.1Kwi involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J MGI:3621037


Genotype
MGI:3621034
hm1
Allelic
Composition		 Gja1tm1.1Kwi/Gja1tm1.1Kwi
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja1tm1.1Kwi mutation (0 available); any Gja1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:78662 )
• homozygotes die within 1 day after birth




Genotype
MGI:3769010
ht2
Allelic
Composition		 Gja1tm1.1Kwi/Gja1+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja1tm1.1Kwi mutation (0 available); any Gja1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal neutrophil physiology ( J:129091 )
• ATP release from polymorphonuclear (PMN) cells is lower than in wild-type PMNs but higher than in null mice

hematopoietic system
abnormal neutrophil physiology ( J:129091 )
• ATP release from polymorphonuclear (PMN) cells is lower than in wild-type PMNs but higher than in null mice




Genotype
MGI:3525604
ht3
Allelic
Composition		 Gja1tm1.1Kwi/Gja1tm4Kwi
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja1tm1.1Kwi mutation (0 available); any Gja1 mutation (60 available)
Gja1tm4Kwi mutation (1 available); any Gja1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:95050 )
• about 50% of compound heterozygotes survive to adulthood

integument
integument phenotype ( J:95050 )
N
• skin appearance and barrier function are normal




Genotype
MGI:3621037
ht4
Allelic
Composition		 Gja1tm1Kdr/Gja1tm1.1Kwi
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja1tm1.1Kwi mutation (0 available); any Gja1 mutation (60 available)
Gja1tm1Kdr mutation (1 available); any Gja1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:78662 )
• homozygotes die within 1 day after birth




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory