Phenotypes associated with this allele

• Allele Symbol: Calca^tm1Hku
• Allele Name: targeted mutation 1, Hiroki Kurihara
• Allele ID: MGI:2445489
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Calca^tm1Hku/Calca^tm1Hku	involves: 129S6/SvEvTac * C57BL/6	MGI:2651377

Genotype
MGI:2651377

hm1

• Allelic Composition: Calca^tm1Hku/Calca^tm1Hku
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

decreased airway responsiveness ( J:80218 )

• reduced bronchial airway responsiveness following methacholine or ovalbumin challenge

• however, eosinophilic infiltration associated with antigen exposure is not altered

• the level of cysteinyl leukotrienes is reduced in sensitized mutants

cardiovascular system

increased systemic vascular resistance ( J:80225 )

• elevation in peripheral vascular resistance by alpha-adrenergic blockade with prazosin and by transthoracic echocardiogram

decreased heart rate variability ( J:80225 )

• heart rate variability, calculated as SDNN index, is smaller in mutants, indicating higher sympathetic tone

increased heart rate ( J:80225 )

• basal heart rate is higher in both anesthetized and conscious, unrestrained mutants

increased mean systemic arterial blood pressure ( J:80225 )

• mean arterial pressure is higher in both anesthetized and conscious, unrestrained mutants

homeostasis/metabolism

abnormal urine catecholamine level ( J:80225 )

• increase in levels of urinary catecholamine metabolites (metanephrine and homovanillic acid)

nervous system

abnormal sympathetic nervous system physiology ( J:80225 )

• basal sympathetic nervous activity is higher as indicated by larger fractional change in heart rate upon atenolol (blocks beta-adrenergic sympathetic neurotransmission) administration and a smaller increases in heart rate upon atropine (blocks muscarinic neurotransmission in the parasympathetic nervous system) administration

• when both atropine and atenolol are administered, mutants show a reduction in heart rate compared to no change in wild-type

renal/urinary system

abnormal urine catecholamine level ( J:80225 )

• increase in levels of urinary catecholamine metabolites (metanephrine and homovanillic acid)