Phenotypes associated with this allele

• Allele Symbol: Cer1^tm1Belo
• Allele Name: targeted mutation 1, Jose Antonio Belo
• Allele ID: MGI:2445497
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cer1^tm1Belo/Cer1^tm1Belo	either: 129X1/SvJ-Cer1^tm1Belo or (involves: 129X1/SvJ * C57BL/6)	MGI:3723107
hm2	Cer1^tm1Belo/Cer1^tm1Belo	involves: 129X1/SvJ	MGI:3723134
cx3	Cer1^tm1Belo/Cer1^tm1Belo Nog^tm1Amc/Nog^tm1Amc	involves: 129S1/Sv * 129X1/SvJ	MGI:3723131
cx4	Cer1^tm1Belo/Cer1^tm1Belo Cripto^tm1Eda/Cripto^tm1Eda	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3851256
cx5	Cer1^tm1Belo/Cer1^tm1Belo Shisa2^tm1Sia/Shisa2^tm1Sia	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:3718479

Genotype
MGI:3723107

hm1

• Allelic Composition: Cer1^tm1Belo/Cer1^tm1Belo
• Genetic Background: either: 129X1/SvJ-Cer1^tm1Belo or (involves: 129X1/SvJ * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:62082 )

• homozygotes are healthy and fertile and show no anterior patterning defects

Genotype
MGI:3723134

hm2

• Allelic Composition: Cer1^tm1Belo/Cer1^tm1Belo
• Genetic Background: involves: 129X1/SvJ

normal phenotype

no abnormal phenotype detected ( J:74136 )

Genotype
MGI:3723131

cx3

• Allelic Composition: Cer1^tm1Belo/Cer1^tm1Belo; Nog^tm1Amc/Nog^tm1Amc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

prenatal lethality ( J:74136 )

• double homozygotes exhibit the same abnormalities as single homozygous Nog mutants

nervous system

abnormal neural tube closure ( J:74136 )

• abnormalities is neural tube closure, particularly in the brain vesicles between the diencephalons and myelencephalon

open neural tube ( J:74136 )

exencephaly ( J:74136 )

• in mutants where the frontal, parietal and interparietal bones are absent, the brain is exposed at birth

skeleton

abnormal basicranium morphology ( J:74136 )

• fusion of presphenoid, basisphenoid, and basioccipital bones

abnormal frontal bone morphology ( J:74136 )

• frontal bone is loose or absent

abnormal interparietal bone morphology ( J:74136 )

• interparietal bones are loose or absent

abnormal occipital bone morphology ( J:74136 )

• occipital condyles are loose, showing variability in the distance separating them

abnormal parietal bone morphology ( J:74136 )

• parietal bone is loose or absent

limbs/digits/tail

short limbs ( J:74136 )

• truncated limbs

absent tail ( J:74136 )

craniofacial

abnormal basicranium morphology ( J:74136 )

• fusion of presphenoid, basisphenoid, and basioccipital bones

abnormal frontal bone morphology ( J:74136 )

• frontal bone is loose or absent

abnormal interparietal bone morphology ( J:74136 )

• interparietal bones are loose or absent

abnormal occipital bone morphology ( J:74136 )

• occipital condyles are loose, showing variability in the distance separating them

abnormal parietal bone morphology ( J:74136 )

• parietal bone is loose or absent

embryo

abnormal neural tube closure ( J:74136 )

• abnormalities is neural tube closure, particularly in the brain vesicles between the diencephalons and myelencephalon

open neural tube ( J:74136 )

Genotype
MGI:3851256

cx4

• Allelic Composition: Cer1^tm1Belo/Cer1^tm1Belo; Cripto^tm1Eda/Cripto^tm1Eda
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

embryo

embryo phenotype ( J:132584 )

N • well developed embyonic region at E9.5

N • migration of anterior visceral endoderm is rescued

abnormal rostral-caudal axis patterning ( J:132584 )

• anterior-posterior axis has developed by E6.5

• delayed at E9.5 relative to controls (equivalent to E8)

• well developed anterior-posterior axis at E8

nervous system

nervous system phenotype ( J:132584 )

N • posterior neuroectoderm is present at E12.5

cardiovascular system

cardiovascular system phenotype ( J:132584 )

N • developing heart is present at E12.5

Genotype
MGI:3718479

cx5

• Allelic Composition: Cer1^tm1Belo/Cer1^tm1Belo; Shisa2^tm1Sia/Shisa2^tm1Sia
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

nervous system

nervous system phenotype ( J:122557 )

N • no defects in anterior neuroectoderm development are detected