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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Seletm1Alb
targeted mutation 1, Arthur L Beaudet
MGI:2445563
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Seletm1Alb/Seletm1Alb involves: 129S7/SvEvBrd * C57BL/6 MGI:3766949
hm2
Seletm1Alb/Seletm1Alb involves: 129S7/SvEvBrd * C57BL/6J MGI:3606626


Genotype
MGI:3766949
hm1
Allelic
Composition
Seletm1Alb/Seletm1Alb
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Seletm1Alb mutation (0 available); any Sele mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• circulating neutrophils are increased in mutants and this increases with age of mice

immune system
• circulating neutrophils are increased in mutants and this increases with age of mice




Genotype
MGI:3606626
hm2
Allelic
Composition
Seletm1Alb/Seletm1Alb
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Seletm1Alb mutation (0 available); any Sele mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increase in splenic thrombosis in contrast to controls following infection with S. pneumoniae
• panophthalmitis observed in 8% of mice following infection with S. pneumoniae
• severity and duration of morbidity higher than wild-type after infection with Streptococcus pneumoniae
• higher S. pneumoniae bacterial load than controls
• survival rate was 7% in contrast to 57% for wild-type
• decreased ability to clear bacteremia among survivors

behavior/neurological
• observed following infection with S. pneumoniae
• observed following infection with S. pneumoniae
• observed following infection with S. pneumoniae
• observed following infection with S. pneumoniae
• observed following infection with S. pneumoniae

growth/size/body
• 48 hours post-infection with S. pneumoniae

vision/eye
• panophthalmitis observed in 8% of mice following infection with S. pneumoniae

hematopoietic system
• increase in splenic thrombosis in contrast to controls following infection with S. pneumoniae





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory