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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Seletm1Alb
targeted mutation 1, Arthur L Beaudet
MGI:2445563
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Seletm1Alb/Seletm1Alb involves: 129S7/SvEvBrd * C57BL/6 MGI:3766949
hm2
 		Seletm1Alb/Seletm1Alb involves: 129S7/SvEvBrd * C57BL/6J MGI:3606626


Genotype
MGI:3766949
hm1
Allelic
Composition		 Seletm1Alb/Seletm1Alb
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Seletm1Alb mutation (0 available); any Sele mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased neutrophil cell number ( J:112286 )
• circulating neutrophils are increased in mutants and this increases with age of mice

immune system
increased neutrophil cell number ( J:112286 )
• circulating neutrophils are increased in mutants and this increases with age of mice




Genotype
MGI:3606626
hm2
Allelic
Composition		 Seletm1Alb/Seletm1Alb
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Seletm1Alb mutation (0 available); any Sele mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal spleen morphology ( J:101979 )
• increase in splenic thrombosis in contrast to controls following infection with S. pneumoniae
eye inflammation ( J:101979 )
• panophthalmitis observed in 8% of mice following infection with S. pneumoniae
increased susceptibility to bacterial infection ( J:101979 )
• severity and duration of morbidity higher than wild-type after infection with Streptococcus pneumoniae
• higher S. pneumoniae bacterial load than controls
• survival rate was 7% in contrast to 57% for wild-type
• decreased ability to clear bacteremia among survivors

behavior/neurological
abnormal pilomotor reflex ( J:101979 )
• observed following infection with S. pneumoniae
tremors ( J:101979 )
• observed following infection with S. pneumoniae
head tilt ( J:101979 )
• observed following infection with S. pneumoniae
decreased locomotor activity ( J:101979 )
• observed following infection with S. pneumoniae
spinning ( J:101979 )
• observed following infection with S. pneumoniae

growth/size/body
weight loss ( J:101979 )
• 48 hours post-infection with S. pneumoniae

vision/eye
eye inflammation ( J:101979 )
• panophthalmitis observed in 8% of mice following infection with S. pneumoniae

hematopoietic system
abnormal spleen morphology ( J:101979 )
• increase in splenic thrombosis in contrast to controls following infection with S. pneumoniae




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/02/2024
MGI 6.13 		The Jackson Laboratory