Phenotypes associated with this allele

• Allele Symbol: Pla2g1b^tm1Dyh
• Allele Name: targeted mutation 1, David Y Hui
• Allele ID: MGI:2445572
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pla2g1b^tm1Dyh/Pla2g1b^tm1Dyh	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6	MGI:3041781

Genotype
MGI:3041781

hm1

• Allelic Composition: Pla2g1b^tm1Dyh/Pla2g1b^tm1Dyh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased white adipose tissue amount ( J:80216 )

• all decreases in adipose tissue involve white fat

decreased epididymal fat pad weight ( J:80216 )

• epididymal fat pad weights were 50% lower than normal

decreased uterine fat pad weight ( J:80216 )

• uterine fat pad weights were 50% lower than normal

digestive/alimentary system

abnormal intestinal lipid absorption ( J:80216 )

• uptake of lipid from the intestine is abnormal

growth/size/body

growth/size/body region phenotype ( J:68430 )

N • body weight normal on a normal fat diet

decreased body weight ( J:80216 )

• less weight gain on a high fat diet

• weight about 2/3 that of controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:68430 )

N • serum cholesterol and triglycerides are normal on a normal diet

abnormal intestinal lipid absorption ( J:80216 )

• uptake of lipid from the intestine is abnormal

decreased circulating leptin level ( J:80216 )

• decreased fasting levels of plasma leptin

abnormal glucose homeostasis ( J:80216 )

abnormal circulating glucose level ( J:80216 )

• plasma glucose levels do not increase on a high fat diet

decreased circulating insulin level ( J:80216 )

• fasting plasma insulin levels are decreased

improved glucose tolerance ( J:80216 )

• improved glucose tolerance compared to controls on a high fat diet

increased insulin sensitivity ( J:80216 )

• insulin sensitivity is improved under both a low and high fat diet

liver/biliary system

decreased liver weight ( J:80216 )

• liver weights were 36% lower in males