Phenotypes associated with this allele

• Allele Symbol: Ptpra^tm1Cjp
• Allele Name: targeted mutation 1, Catherine J Pallen
• Allele ID: MGI:2445612
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptpra^tm1Cjp/Ptpra^tm1Cjp	involves: 129X1/SvJ	MGI:3820314
hm2	Ptpra^tm1Cjp/Ptpra^tm1Cjp	involves: 129X1/SvJ * Black Swiss	MGI:3820235

Genotype
MGI:3820314

hm1

• Allelic Composition: Ptpra^tm1Cjp/Ptpra^tm1Cjp
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal cerebral cortex pyramidal cell morphology ( J:130375 )

• mutants exhibit misoriented, even inverted, apical dendrites in layer V pyramidal neurons in the somatosensory and visual cortices and misoriented dendrites in the motor cortex

Genotype
MGI:3820235

hm2

• Allelic Composition: Ptpra^tm1Cjp/Ptpra^tm1Cjp
• Genetic Background: involves: 129X1/SvJ * Black Swiss

behavior/neurological

abnormal spatial learning ( J:85438 )

• in the Morris water maze learning, mutants show increased latencies to reach the hidden platform compared to wild-type on acquisition, but no memory deficits on probe trials

decreased anxiety-related response ( J:85438 )

• homozygotes spend about 20% more time in the open areas of the zero-maze indicating decreased anxiety, however they do not show differences in head dips and stretch-attend movements

decreased vertical activity ( J:85438 )

• decrease in both horizontal and vertical activity

decreased locomotor activity ( J:85438 )

• mutants show decreased exploratory locomotor activity, but respond normally to a challenge dose of D-methamphetamine

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:87936 )

N • mutants have normal body weights, circulating levels of glucose and insulin in fed and fasted states, and blood glucose clearance in glucose and insulin tolerance tests, however they show a reduced, or more rapidly attenuated, insulin-stimulated interaction between IRS-1 and PI3-K in the liver