All Phenotypes Ptpra<tm1Cjp> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptpra^tm1Cjp/Ptpra^tm1Cjp	involves: 129X1/SvJ	MGI:3820314
hm2	Ptpra^tm1Cjp/Ptpra^tm1Cjp	involves: 129X1/SvJ * Black Swiss	MGI:3820235

Allelic Composition	Ptpra^tm1Cjp/Ptpra^tm1Cjp
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpra^tm1Cjp mutation (0 available); any Ptpra mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebral cortex pyramidal cell morphology ( J:130375 )

• mutants exhibit misoriented, even inverted, apical dendrites in layer V pyramidal neurons in the somatosensory and visual cortices and misoriented dendrites in the motor cortex

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal spatial learning ( J:85438 )

• in the Morris water maze learning, mutants show increased latencies to reach the hidden platform compared to wild-type on acquisition, but no memory deficits on probe trials

decreased anxiety-related response ( J:85438 )

• homozygotes spend about 20% more time in the open areas of the zero-maze indicating decreased anxiety, however they do not show differences in head dips and stretch-attend movements

decreased vertical activity ( J:85438 )

• decrease in both horizontal and vertical activity

decreased locomotor activity ( J:85438 )

• mutants show decreased exploratory locomotor activity, but respond normally to a challenge dose of D-methamphetamine

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:87936 )

N	• mutants have normal body weights, circulating levels of glucose and insulin in fed and fasted states, and blood glucose clearance in glucose and insulin tolerance tests, however they show a reduced, or more rapidly attenuated, insulin-stimulated interaction between IRS-1 and PI3-K in the liver

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24