Phenotypes associated with this allele

• Allele Symbol: Tarbp2^tm1Reb
• Allele Name: targeted mutation 1, Robert E Braun
• Allele ID: MGI:2445673
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tarbp2^tm1Reb/Tarbp2^tm1Reb	Not Specified	MGI:3033595

Genotype
MGI:3033595

hm1

• Allelic Composition: Tarbp2^tm1Reb/Tarbp2^tm1Reb
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality at weaning, complete penetrance ( J:55515 )

• most homozygotes die at the time of weaning, unless rescued with a dietary supplement; these animals lived for 6-10 months

growth/size/body

decreased body weight ( J:55515 )

• homozygotes weigh approximately half as much as controls

reproductive system

oligozoospermia ( J:55515 )

♂ • sperm counts on homozygous males are less than 0.5% of controls

♂ • the epididymis contains mostly degenerating spermatids

abnormal spermiogenesis ( J:55515 )

♂ • appearance of symplasts was noted, along with defects in the differentiation of elongated spermatids and incomplete release of spermatozoa in tubules

male infertility ( J:55515 )

♂ • although homozygous males of mating age exhibited normal mating behavior and could plug females, females did not become pregnant

cellular

oligozoospermia ( J:55515 )

♂ • sperm counts on homozygous males are less than 0.5% of controls

♂ • the epididymis contains mostly degenerating spermatids