Phenotypes associated with this allele

• Allele Symbol: Serpina5^tm1Gei
• Allele Name: targeted mutation 1, Margarethe Geiger
• Allele ID: MGI:2445835
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Serpina5^tm1Gei/Serpina5^tm1Gei	involves: 129/Sv * Swiss	MGI:3037885

Genotype
MGI:3037885

hm1

• Allelic Composition: Serpina5^tm1Gei/Serpina5^tm1Gei
• Genetic Background: involves: 129/Sv * Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

asthenozoospermia ( J:66422 )

♂ • only about 12.5% of sperm actually motile

abnormal gametogenesis ( J:66422 )

teratozoospermia ( J:66422 )

♂ • 95% of sperm morphologically abnormal, most lack tails, some with malformed heads

abnormal male reproductive system morphology ( J:66422 )

♂

abnormal seminiferous tubule morphology ( J:66422 )

♂ • tubules filled with cells at varying stages of spermatogenesis, some apoptotic

abnormal Sertoli cell morphology ( J:66422 )

♂ • Sertoli cells with vacuolated cytoplasm

abnormal epididymis epithelium morphology ( J:66422 )

♂ • misshaped or missing epithelium lining the duct of the epididymis

male infertility ( J:66422 )

♂ • male infertility does not involve sexual activity

abnormal fertilization ( J:66422 )

• sperm do not bind with eggs

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:66422 )

♂ • tubules filled with cells at varying stages of spermatogenesis, some apoptotic

abnormal Sertoli cell morphology ( J:66422 )

♂ • Sertoli cells with vacuolated cytoplasm

cellular

teratozoospermia ( J:66422 )

♂ • 95% of sperm morphologically abnormal, most lack tails, some with malformed heads

asthenozoospermia ( J:66422 )

♂ • only about 12.5% of sperm actually motile