About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Arid5btm1Pjh
targeted mutation 1, Paul J Hertzog
MGI:2445941
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Arid5btm1Pjh/Arid5btm1Pjh involves: 129S4/SvJae * BALB/c MGI:3698629


Genotype
MGI:3698629
hm1
Allelic
Composition
Arid5btm1Pjh/Arid5btm1Pjh
Genetic
Background
involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid5btm1Pjh mutation (0 available); any Arid5b mutation (136 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes are considerably reduced in numbers at 1 day after birth
• normal survival from 1 day of age to 1 year

growth/size/body
• survivors remain smaller than controls
• emaciated appearance
• mean weight is 80% of controls in the first day after birth
• significantly reduced growth rate prior to weaning
• weight is 69% of controls at 6.5 weeks of age
• weight deficits are never recovered

behavior/neurological
• ungroomed coat
• mating behavior of males is reduced with reduced plug formation when mated to control females
• females ""plug"" less frequently when mated with wild-type males

reproductive system
• reduced uterine gland size
• development only to the antral stage
• reduced size due to reductions in the muscularis layer as well as the uterine stroma and strata basalae
• increased incidence of disruption but only in undescended testes
• round and elongated spermatids are rare
• many cells at the luminal border of the epithelium in the undescended testes are degenerating
• multinucleated giant cells are often seen in the undescended testes
• undescended testes are small
• may be unilateral or bilateral
• follicular development does not continue beyond antral stage
• reduced mating behavior
• disruption of spermatogenesis in undescended testes

endocrine/exocrine glands
• thickness of the zona reticularis is reduced
• other regions of the adrenal are not consistently altered
• adrenal cell types are normal
• thinning of the cortex with reduced numbers of lymphocytes
• reduced cellularity
• reduced uterine gland size
• development only to the antral stage
• many cells at the luminal border of the epithelium in the undescended testes are degenerating
• multinucleated giant cells are often seen in the undescended testes
• undescended testes are small
• may be unilateral or bilateral

immune system
• at 4 weeks of age but not at 6 weeks of age
• reduced proportion of early B cell progenitor cells seen at 4 weeks but not at 6 weeks of age
• decreased numbers of double positive T cells in thymus at 4 weeks of age but not a 6 weeks
• increased numbers of single positive T cells in thymus at 4 weeks of age but not a 6 weeks
• at 4 weeks of age but not at 6 weeks
• thinning of the cortex with reduced numbers of lymphocytes
• reduced cellularity
• reduced cellularity but overall spleen architecture is normal

hematopoietic system
• thinning of the cortex with reduced numbers of lymphocytes
• reduced cellularity
• at 4 weeks of age but not at 6 weeks of age
• reduced proportion of early B cell progenitor cells seen at 4 weeks but not at 6 weeks of age
• decreased numbers of double positive T cells in thymus at 4 weeks of age but not a 6 weeks
• reduced cellularity
• increased numbers of single positive T cells in thymus at 4 weeks of age but not a 6 weeks
• reduced cellularity but overall spleen architecture is normal





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory