About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		KitlSl-22R
steel 22 Oak Ridge
MGI:2445944
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		KitlSl-22R/KitlSl-22R C3H-KitlSl-22R MGI:3794419
ht2
 		KitlSl-22R/Kitl+ C3H-KitlSl-22R MGI:3794420


Genotype
MGI:3794419
hm1
Allelic
Composition		 KitlSl-22R/KitlSl-22R
Genetic
Background		 C3H-KitlSl-22R
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitlSl-22R mutation (0 available); any Kitl mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:79293 )
• no animals survive beyond P18
perinatal lethality, incomplete penetrance ( J:79293 )
• only 61-71% of expected numbers are observed at P1

reproductive system
decreased primordial germ cell number ( J:115437 )
• primordial germ cells are severely reduced in number or absent compared to wild-type in genital ridges at E11.5

hematopoietic system
macrocytic anemia ( J:79293 )
• severe at birth
low mean erythrocyte cell number ( J:79293 )
• significantly lower than wild-type at birth (20% of wild-type value)

cellular
decreased primordial germ cell number ( J:115437 )
• primordial germ cells are severely reduced in number or absent compared to wild-type in genital ridges at E11.5




Genotype
MGI:3794420
ht2
Allelic
Composition		 KitlSl-22R/Kitl+
Genetic
Background		 C3H-KitlSl-22R
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitlSl-22R mutation (0 available); any Kitl mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:79293 )
N
• at P1, mean red blood cell (RBC) counts are not different from wild-type mean (4.1 x 109 cells/ml)
macrocytic anemia ( J:79293 )
• mild at birth
increased mean corpuscular hemoglobin ( J:79293 )
• significantly increased compared to wild-type at P24-25
increased mean corpuscular volume ( J:79293 )
• significantly increased compared to wild-type at P24-25

pigmentation

integument




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory