Phenotypes associated with this allele

• Allele Symbol: Kitl^Sl-28R
• Allele Name: steel 28 Oak Ridge
• Allele ID: MGI:2445945
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kitl^Sl-28R/Kitl^Sl-28R	C3.101Rl-Kitl^Sl-28R	MGI:3794425
ht2	Kitl^Sl-28R/Kitl^+	C3.101Rl-Kitl^Sl-28R	MGI:3794426

Genotype
MGI:3794425

hm1

• Allelic Composition: Kitl^Sl-28R/Kitl^Sl-28R
• Genetic Background: C3.101Rl-Kitl^Sl-28R

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:79293 )

• no animals survive beyond P18

perinatal lethality, incomplete penetrance ( J:79293 )

• only 61-71% of expected numbers are observed at P1

prenatal lethality, incomplete penetrance ( J:79293 )

reproductive system

decreased primordial germ cell number ( J:115437 )

• primordial germ cells are severely reduced in number or absent compared to wild-type in genital ridges at E11.5

hematopoietic system

macrocytic anemia ( J:79293 )

• severe at birth

low mean erythrocyte cell number ( J:79293 )

• significantly lower than wild-type at birth

cellular

decreased primordial germ cell number ( J:115437 )

• primordial germ cells are severely reduced in number or absent compared to wild-type in genital ridges at E11.5

Genotype
MGI:3794426

ht2

• Allelic Composition: Kitl^Sl-28R/Kitl⁺
• Genetic Background: C3.101Rl-Kitl^Sl-28R

hematopoietic system

macrocytic anemia ( J:79293 )

• mild at birth

increased mean corpuscular hemoglobin ( J:79293 )

• significantly increased compared to wild-type at P24-25

increased mean corpuscular volume ( J:79293 )

• significantly increased compared to wild-type at P24-25

pigmentation

abnormal ventral coat pigmentation ( J:79293 )

• diluted ventrum

head spot ( J:79293 )

integument

abnormal ventral coat pigmentation ( J:79293 )

• diluted ventrum

head spot ( J:79293 )