All Phenotypes Kitl<Sl-39R> MGI Mouse

postnatal lethality, incomplete penetrance ( J:79293 )

• 73% of mice survive to P18

abnormal primordial germ cell morphology ( J:115437 )

• many PGCs with abnormal morphology are retained in the hindgut at E10.5

decreased primordial germ cell number ( J:115437 )

• moderate numbers of primordial germ cells (PGCs) are seen in genital ridges relative to wild-type and Kitl^Sl-gb homozygotes at E11.5

• at E9.5, PGC numbers in the hindgut are 44% of wild-type

increased primordial germ cell apoptosis ( J:115437 )

• at E10.5, many PGCs in hindgut appear to be disintegrating; abnormal PGCs in hindgut tend to be nonmotile and apoptotic

abnormal primordial germ cell migration ( J:115437 )

• at E10.5, only 50% of total PGCs have migrated from hindgut, compared to 93% in wild-type

decreased primordial germ cell proliferation ( J:115437 )

• proliferation indices of migratory (in mesentery and genital ridges) and postmigratory PGCs (in genital ridges) at 10.5 and 11.5 are significantly reduced compared to wild-type values (54-66% of wild-type values)

abnormal coat/hair pigmentation ( J:79293 )

• some animals have pigmented patches on their heads

macrocytic anemia ( J:79293 )

• severe at birth

low mean erythrocyte cell number ( J:79293 )

• significantly lower than wild-type at birth (34% of wild-type value)

decreased hematocrit ( J:79293 )

• significantly lower than wild-type at P24-25

increased mean corpuscular hemoglobin ( J:79293 )

• significantly increased compared to wild-type at P24-25

increased mean corpuscular hemoglobin concentration ( J:79293 )

• increased compared to wild-type at P24-25

increased mean corpuscular volume ( J:79293 )