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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		KitlSl-36R
steel 36 Oak Ridge
MGI:2445948
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		KitlSl-36R/KitlSl-36R C3H-KitlSl-36R MGI:3794423
ht2
 		KitlSl-36R/Kitl+ C3H-KitlSl-36R MGI:3794424


Genotype
MGI:3794423
hm1
Allelic
Composition		 KitlSl-36R/KitlSl-36R
Genetic
Background		 C3H-KitlSl-36R
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitlSl-36R mutation (0 available); any Kitl mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:79293 )
• 63% of mice survive to P18; most deaths occur prior to P7

reproductive system
decreased primordial germ cell number ( J:115437 )
• moderate numbers of primordial germ cells (PGCs) are seen in genital ridges relative to wild-type and KitlSl-gb homozygotes at E11.5
• at E9.5, PGC numbers in the hindgut are 44% of wild-type
abnormal primordial germ cell migration ( J:115437 )
• at E10.5, 83% of total PGCs have migrated from hindgut, compared to 93% in wild-type
decreased primordial germ cell proliferation ( J:115437 )
• proliferation indices of migratory (in mesentery and genital ridges) and postmigratory PGCs (in genital ridges) at 10.5 and 11.5 are significantly reduced compared to wild-type values (54-66% of wild-type values)

hematopoietic system
low mean erythrocyte cell number ( J:79293 )
• significantly lower than wild-type at birth (41% of wild-type value)
decreased hematocrit ( J:79293 )
• significantly lower than wild-type at P24-25
increased mean corpuscular hemoglobin ( J:79293 )
• significantly increased compared to wild-type at P24-25
increased mean corpuscular hemoglobin concentration ( J:79293 )
• significantly increased compared to wild-type at P24-25

cellular
decreased primordial germ cell number ( J:115437 )
• moderate numbers of primordial germ cells (PGCs) are seen in genital ridges relative to wild-type and KitlSl-gb homozygotes at E11.5
• at E9.5, PGC numbers in the hindgut are 44% of wild-type
abnormal primordial germ cell migration ( J:115437 )
• at E10.5, 83% of total PGCs have migrated from hindgut, compared to 93% in wild-type
decreased primordial germ cell proliferation ( J:115437 )
• proliferation indices of migratory (in mesentery and genital ridges) and postmigratory PGCs (in genital ridges) at 10.5 and 11.5 are significantly reduced compared to wild-type values (54-66% of wild-type values)




Genotype
MGI:3794424
ht2
Allelic
Composition		 KitlSl-36R/Kitl+
Genetic
Background		 C3H-KitlSl-36R
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitlSl-36R mutation (0 available); any Kitl mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
macrocytic anemia ( J:79293 )
• mild at birth
low mean erythrocyte cell number ( J:79293 )
• at P1, mean red blood cell (RBC) counts are not different from KitlSl-d / KitlSl-gb compound heterozygotes (2.9 x 109 cells/ml; 4.1 x 109 cells/ml in wild-type mice)
increased mean corpuscular hemoglobin ( J:79293 )
• significantly increased compared to wild-type at P24-25
increased mean corpuscular volume ( J:79293 )
• significantly increased compared to wild-type at P24-25

pigmentation

integument




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory