Phenotypes associated with this allele

• Allele Symbol: Tg(LPV-TAg121)2Tvd
• Allele Name: transgene insertion 2, Terry van Dyke
• Allele ID: MGI:2445949
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Smarcb1^tm1Sho/Smarcb1^+ Tg(LPV-TAg121)2Tvd/0	involves: 129S6/SvEvTac * C57BL/6J * DBA/2J	MGI:5538529
tg2	Tg(LPV-TAg121)2Tvd/0	involves: 129S6/SvEvTac * C57BL/6J * DBA/2J	MGI:5538528

Genotype
MGI:5538529

cx1

• Allelic Composition: Smarcb1^tm1Sho/Smarcb1⁺; Tg(LPV-TAg121)2Tvd/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased malignant tumor incidence ( J:120820 )

• malignant rhabdoid tumors develop with increased frequency (55%) and reduced latency (median, 4.9 months) compared to single Smarcb1 heterozygotes

• both soft tissue and CNS tumor frequencies increase (32% and 24%, respectively)

• 44% of malignant rhabdoid tumors are located around the roots or spinal nerves within the spinal cord, most frequently near the thoracolumbar junction with a median age of 5.2 months

• malignant rhabdoid tumors have a more than a 4-fold increase in mitotic index compared with single Smarcb1 heterozygotes

increased carcinoma incidence ( J:120820 )

• 100% penetrance of choroid plexus carcinomas, with a median latency of 9 months, similar to single Tg(LPV-TAg121)2Tvd mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atypical teratoid rhabdoid tumor		DOID:2129	OMIM:609322	J:120820
choroid plexus papilloma		DOID:2626	OMIM:260500	J:120820

Genotype
MGI:5538528

tg2

• Allelic Composition: Tg(LPV-TAg121)2Tvd/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * DBA/2J

nervous system

abnormal choroid plexus morphology ( J:120820 )

• choroid plexus epithelium is dysplastic until about 6 weeks of age after which tumors begin to develop

neoplasm

increased carcinoma incidence ( J:120820 )

• 100% penetrance of choroid plexus carcinomas, with median latency of 9 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
choroid plexus papilloma		DOID:2626	OMIM:260500	J:120820