Phenotypes associated with this allele

• Allele Symbol: F2rl2^tm1Cgh
• Allele Name: targeted mutation 1, Shaun R Coughlin
• Allele ID: MGI:2445957
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	F2rl2^tm1Cgh/F2rl2^tm1Cgh	involves: 129S4/SvJae * C57BL/6	MGI:3665301

Genotype
MGI:3665301

hm1

• Allelic Composition: F2rl2^tm1Cgh/F2rl2^tm1Cgh
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal platelet physiology ( J:49283 )

• platelet responses require a 10X higher thrombin concentration than controls and response is delayed

• platelet secretion levels always lower than controls

• platelet secretion reaches normal levels when thrombin levels are 30X normal

decreased susceptibility to induced thrombosis ( J:80154 )

• resistant to ferric chloride injury, arterioles tend to remain open more than 30 minutes after application of ferric chloride

• much better survival after injections of thromboplastin into the vena cava

• fewer thrombi form in the lungs and they are usually non-occlusive

increased bleeding time ( J:80154 )

• prolonged bleeding times

hematopoietic system

abnormal platelet physiology ( J:49283 )

• platelet responses require a 10X higher thrombin concentration than controls and response is delayed

• platelet secretion levels always lower than controls

• platelet secretion reaches normal levels when thrombin levels are 30X normal