Phenotypes associated with this allele

• Allele Symbol: Evx2^tm1Ddu
• Allele Name: targeted mutation 1, Denis Duboule
• Allele ID: MGI:2445967
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Evx2^tm1Ddu/Evx2^tm1Ddu	involves: 129S2/SvPas * C57BL/6J	MGI:3720780

Genotype
MGI:3720780

hm1

• Allelic Composition: Evx2^tm1Ddu/Evx2^tm1Ddu
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

male infertility ( J:37211 )

♂ • male mice do not breed

limbs/digits/tail

abnormal carpal bone morphology ( J:37211 )

• d3 and d4 are malformed

• in the distal row of carpal, central carpals extend below d2 and d3 while d3 points to the basis of metacarpal III

• d4 has an abnormal indentation and during condensation is split into several parts

• an extra condensation occurs (termed d5*) that associated with the proximal part of metacarpal V

abnormal digit morphology ( J:37211 )

• digit V is malformed

• the second phalanges of digit V is greatly reduced while the metacarpal is broader and abnormally enlarged

abnormal phalanx morphology ( J:37211 )

• the second phalanges of digit V is greatly reduced

brachyphalangia ( J:37211 )

abnormal metacarpal bone morphology ( J:37211 )

• the metacarpal of digit V is broader and abnormally enlarged proximally

• an extra consensation occurs (termed d5*) that associated with the proximal part of metacarpal V

• metacarpus I of the hindlimb is moderately reduced

short metacarpal bones ( J:37211 )

short limbs ( J:37211 )

growth/size/body

decreased body weight ( J:37211 )

• mice weigh 30% less than wild-type mice at birth

skeleton

abnormal carpal bone morphology ( J:37211 )

• d3 and d4 are malformed

• in the distal row of carpal, central carpals extend below d2 and d3 while d3 points to the basis of metacarpal III

• d4 has an abnormal indentation and during condensation is split into several parts

• an extra condensation occurs (termed d5*) that associated with the proximal part of metacarpal V

abnormal phalanx morphology ( J:37211 )

• the second phalanges of digit V is greatly reduced

brachyphalangia ( J:37211 )

abnormal metacarpal bone morphology ( J:37211 )

• metacarpus I of the hindlimb is moderately reduced

• the metacarpal of digit V is broader and abnormally enlarged proximally

• an extra consensation occurs (termed d5*) that associated with the proximal part of metacarpal V

short metacarpal bones ( J:37211 )