Phenotypes associated with this allele

• Allele Symbol: Evx2^tm3Ddu
• Allele Name: targeted mutation 3, Denis Duboule
• Allele ID: MGI:2445968
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Evx2^tm3Ddu/Evx2^tm3Ddu Hoxd13^tm3Ddu/Hoxd13^tm3Ddu	involves: 129S2/SvPas * C57BL/6	MGI:3720777

Genotype
MGI:3720777

cx1

• Allelic Composition: Evx2^tm3Ddu/Evx2^tm3Ddu; Hoxd13^tm3Ddu/Hoxd13^tm3Ddu
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

male infertility ( J:37211 )

♂ • male mice do not breed

♂ • however, no gross abnormalities in urogenital apparatus are observed

limbs/digits/tail

abnormal carpal bone morphology ( J:37211 )

• the split observed in d4 during condensation is more pronounced than in Evx2^tm1Ddu homozygotes

• supernumerary d5 and d5* bones fuse to the basis of metacarpal V

abnormal digit morphology ( J:37211 )

• the second phalanges of digit V and II are missing and metacarpal V is reduced and broader

• the bony elements of digit II or III are fused and produces continuous, rigid bone rods

• an extra, non-segmented bone (digit VI) appears post-axially in 80% of mice

abnormal phalanx morphology ( J:37211 )

• the second phalanges of digit V and II are missing

polydactyly ( J:37211 )

• an extra, non-segmented bone (digitVI) appears post-axially in 80% of mice

abnormal metacarpal bone morphology ( J:37211 )

• metacarpal V is reduced and broader

• supernumerary d5 and d5* bones fuse to the basis of metacarpal V

• metacarpus I of the hindlimb is more severely reduced than in Evx2^tm1Ddu homozygotes

short limbs ( J:37211 )

growth/size/body

decreased body weight ( J:37211 )

• mice weigh 30% less than wild-type mice at birth

skeleton

abnormal carpal bone morphology ( J:37211 )

• the split observed in d4 during condensation is more pronounced than in Evx2^tm1Ddu homozygotes

• supernumerary d5 and d5* bones fuse to the basis of metacarpal V

abnormal phalanx morphology ( J:37211 )

• the second phalanges of digit V and II are missing

abnormal metacarpal bone morphology ( J:37211 )

• metacarpal V is reduced and broader

• supernumerary d5 and d5* bones fuse to the basis of metacarpal V

• metacarpus I of the hindlimb is more severely reduced than in Evx2^tm1Ddu homozygotes