Phenotypes associated with this allele

• Allele Symbol: Evx2^tm2Ddu
• Allele Name: targeted mutation 2, Denis Duboule
• Allele ID: MGI:2445970
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Evx2^tm2Ddu/Evx2^tm2Ddu Hoxd13^tm1Ddu/Hoxd13^tm1Ddu	involves: 129S2/SvPas * C57BL/6	MGI:3720779

Genotype
MGI:3720779

cx1

• Allelic Composition: Evx2^tm2Ddu/Evx2^tm2Ddu; Hoxd13^tm1Ddu/Hoxd13^tm1Ddu
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:37211 )

• 50% of mice die postnatally

limbs/digits/tail

abnormal carpal bone morphology ( J:37211 )

• wrist deformations are more severe than in Evx2^tm1Ddu homozygotes

• the central bone is flattened and d3 is abnormal

• d4 forms a small bone

• an extra d5 element (d5*) either contacts the basis of an extra digit VI or fuses to d5

• several small ectopic bones appear between the metacarpals that eventually fuse together with underlying carpal bones or with the metacarpus

abnormal digit morphology ( J:37211 )

• phalange 2 is missing from digits II and V

• the thumb is abnormal and appears as a single block with a hole at the level of the fusion between phalange 1 and the metacarpal

• an extra d5 element (d5*) either contacts the basis of an extra digit VI or fuses to d5

• digit I in the hindlimb consists of a single metacarpo-phalangeal element

• digits II and V of the hindlimb are abnormal

• an extra digit is found in the hindlimb

abnormal phalanx morphology ( J:37211 )

• phalanges are reduced and deformed

• phalange 2 is missing from digits II and V

• fusion occurs at most articulations resulting in a single metacarpo-phalangeal element

• phalange 1 fuses to the metacarpal

brachyphalangia ( J:37211 )

• all digits are markedly shorter

polydactyly ( J:37211 )

• a seventh digit forms from the post-axial rudimentary bones

• an extra digit is found in the hindlimb

abnormal tarsal bone morphology ( J:37211 )

• a supernumerary tarsal bone is found in the hindlimb

abnormal metacarpal bone morphology ( J:37211 )

• metacarpals are reduced and deformed

• fusion occurs at most articulations resulting in a single metacarpo-phalangeal element

• phalange 1 fuses to the metacarpal

• several small ectopic bones appear between the metacarpals that eventually fuse together with underlying carpal bones or with the metacarpus

growth/size/body

decreased body weight ( J:37211 )

• mice weigh up to 50% less than wild-type mice at birth

skeleton

abnormal carpal bone morphology ( J:37211 )

• wrist deformations are more severe than in Evx2^tm1Ddu homozygotes

• the central bone is flattened and d3 is abnormal

• d4 forms a small bone

• an extra d5 element (d5*) either contacts the basis of an extra digit VI or fuses to d5

• several small ectopic bones appear between the metacarpals that eventually fuse together with underlying carpal bones or with the metacarpus

abnormal phalanx morphology ( J:37211 )

• phalanges are reduced and deformed

• phalange 2 is missing from digits II and V

• fusion occurs at most articulations resulting in a single metacarpo-phalangeal element

• phalange 1 fuses to the metacarpal

brachyphalangia ( J:37211 )

• all digits are markedly shorter

abnormal tarsal bone morphology ( J:37211 )

• a supernumerary tarsal bone is found in the hindlimb

abnormal metacarpal bone morphology ( J:37211 )

• metacarpals are reduced and deformed

• fusion occurs at most articulations resulting in a single metacarpo-phalangeal element

• phalange 1 fuses to the metacarpal

• several small ectopic bones appear between the metacarpals that eventually fuse together with underlying carpal bones or with the metacarpus