Phenotypes associated with this allele

• Allele Symbol: Tg(Hba-x-v-Ha-ras)TG.ACLed
• Allele Name: transgene insertion TG.AC, Philip Leder
• Allele ID: MGI:2445993
• Summary: 7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Hba-x-v-Ha-ras)TG.ACLed/0 Wrn^tm1Led/Wrn^tm1Led	involves: 129 * FVB/N * Black Swiss	MGI:2651804
cx2	Dgki^tm1Mtop/Dgki^tm1Mtop Tg(Hba-x-v-Ha-ras)TG.ACLed/0	involves: 129S1/Sv * 129X1/SvJ * FVB/NTac	MGI:3589794
cx3	Ksr1^tm1Kole/Ksr1^tm1Kole Tg(Hba-x-v-Ha-ras)TG.ACLed/0	involves: 129S1/Sv * C57BL/6 * FVB/N	MGI:2670741
cx4	Tg(Hba-x-v-Ha-ras)TG.ACLed/0 Tg(KRT5-cre)1Tak/Tg(KRT5-cre)1Tak	involves: C3H * C57BL/6 * FVB/NTac	MGI:6404055
cx5	Cebpb^tm1Pfj/Cebpb^tm1Pfj Tg(Hba-x-v-Ha-ras)TG.ACLed/0	involves: C57BL/6	MGI:3510871
tg6	Tg(Hba-x-v-Ha-ras)TG.ACLed/0	involves: 129 * FVB/N * Black Swiss	MGI:2651809
tg7	Tg(Hba-x-v-Ha-ras)TG.ACLed/0	involves: FVB/N	MGI:2651810

Genotype
MGI:2651804

cx1

• Allelic Composition: Tg(Hba-x-v-Ha-ras)TG.ACLed/0; Wrn^tm1Led/Wrn^tm1Led
• Genetic Background: involves: 129 * FVB/N * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:79056 )

• increased skin and fore-stomach papilloma incidence after TPA-treatment

increased papilloma incidence ( J:79056 )

• increased fore-stomach papilloma incident with or without TPA-treatment

• increased skin papilloma incidence after TPA-treatment

growth/size/body

weight loss ( J:79056 )

• dramatic weight loss between 6 and 8 months of age

• weight loss accompanies fore-stomach papilloma development

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:79056 )

• increased skin and fore-stomach papilloma incidence after TPA-treatment

Genotype
MGI:3589794

cx2

• Allelic Composition: Dgki^tm1Mtop/Dgki^tm1Mtop; Tg(Hba-x-v-Ha-ras)TG.ACLed/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NTac

neoplasm

decreased incidence of induced tumors ( J:99817 )

• skin tumors induced by application of PMA or by full-thickness skin wounding are fewer in Dgki^tm1Mtop homozygotes carrying the v-Ha-ras transgene compared to wild-type, transgene-positive mice

Genotype
MGI:2670741

cx3

• Allelic Composition: Ksr1^tm1Kole/Ksr1^tm1Kole; Tg(Hba-x-v-Ha-ras)TG.ACLed/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

neoplasm

decreased incidence of tumors by chemical induction ( J:84644 )

• only 10% of TPA-treated homozygotes carrying the Tg(Hba-x-v-Ha-ras)TG.ACLed transgene develop Ras-induced papillomas versus 70% of wild-type, transgene-positive control mice, with a similar average number of papillomas (2-4 per mouse) in each group

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:84644 )

• only 10% of TPA-treated homozygotes carrying the Tg(Hba-x-v-Ha-ras)TG.ACLed transgene develop Ras-induced papillomas versus 70% of wild-type, transgene-positive control mice, with a similar average number of papillomas (2-4 per mouse) in each group

Genotype
MGI:6404055

cx4

• Allelic Composition: Tg(Hba-x-v-Ha-ras)TG.ACLed/0; Tg(KRT5-cre)1Tak/Tg(KRT5-cre)1Tak
• Genetic Background: involves: C3H * C57BL/6 * FVB/NTac

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:120797 )

• quicker progression from papillomas to malignant skin tumors in TPA-treated mice

• however, the number of TPA-induced papillomas is normal

neoplasm

increased incidence of tumors by chemical induction ( J:120797 )

• quicker progression from papillomas to malignant skin tumors in TPA-treated mice

• however, the number of TPA-induced papillomas is normal

Genotype
MGI:3510871

cx5

• Allelic Composition: Cebpb^tm1Pfj/Cebpb^tm1Pfj; Tg(Hba-x-v-Ha-ras)TG.ACLed/0
• Genetic Background: involves: C57BL/6

neoplasm

decreased incidence of tumors by chemical induction ( J:73558 )

• TPA-treated Cebpb^tm1Pfj homozygotes carrying the v-Ha-ras transgene develop 65% fewer Ras-induced papillomas than wild-type, transgene-positive mice

decreased tumor growth/size ( J:73558 )

• notably, the tumor size is reduced by 60% in the Cebpb^tm1Pfj homozygous null background

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:73558 )

• TPA-treated Cebpb^tm1Pfj homozygotes carrying the v-Ha-ras transgene develop 65% fewer Ras-induced papillomas than wild-type, transgene-positive mice

Genotype
MGI:2651809

tg6

• Allelic Composition: Tg(Hba-x-v-Ha-ras)TG.ACLed/0
• Genetic Background: involves: 129 * FVB/N * Black Swiss

neoplasm

increased papilloma incidence ( J:79056 )

• Background Sensitivity: animals on an FVB/N/129/Black Swiss mixed genetic background display 52% papilloma incidence 10 weeks after start of TPA-treatment; these papillomas first appear 6 weeks after TPA-treatment

increased incidence of induced tumors ( J:79056 )

Genotype
MGI:2651810

tg7

• Allelic Composition: Tg(Hba-x-v-Ha-ras)TG.ACLed/0
• Genetic Background: involves: FVB/N

neoplasm

increased papilloma incidence ( J:79056 )

• Background Sensitivity: animals with an FVB/N genetic background display 90% papilloma incidence 10 weeks after start of TPA-treatment; these papillomas first appear 4 weeks after TPA-treatment

increased incidence of induced tumors ( J:79056 )