Analysis Tools|
Allele Symbol Allele Name Allele ID |
Hoxdtm11Ddu targeted mutation 11, Denis Duboule MGI:2446018 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• a size reduction of bony elements in particular digits II and V, and a generally stiffer and poorly formed aspect resembling phenotype observed in homozygous Hoxd13tm1Ddu
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• some mice carrying both mutant loci in trans lack the joint between P1 and P2 in digit III
• all forelimbs of mice carrying both mutant loci in trans exhibit a supernumerary postaxial bony element
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• mice carrying both mutant loci in trans show loss of phalange 2 in digit II
• most mice carrying both mutant loci in trans lose phalange 2 in digit V
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• the first metatarsal of hindlimbs is dysmorphic in mice carrying both mutant loci in trans, with an aberrantly thick and shorter aspect, and is occasionally fused to P1
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• mice carrying both mutant loci in trans show loss of phalange 2 in digit II
• most mice carrying both mutant loci in trans lose phalange 2 in digit V
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• the first metatarsal of hindlimbs is dysmorphic in mice carrying both mutant loci in trans, with an aberrantly thick and shorter aspect, and is occasionally fused to P1
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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