All Phenotypes Irf9<tm1Ttg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Irf9^tm1Ttg
targeted mutation 1, Tadatsugu Taniguchi
MGI:2446102

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Irf9^tm1Ttg/Irf9^tm1Ttg	B6.Cg-Irf9^tm1Ttg	MGI:3577714
hm2	Irf9^tm1Ttg/Irf9^tm1Ttg	either: (involves: C57BL/6 * CBA * ICR) or (involves: A/J * C57BL/6 * CBA)	MGI:3584014
cx3	Irf3^tm1Ttg/Irf3^tm1Ttg Irf9^tm1Ttg/Irf9^tm1Ttg	involves: 129S/SvEv * C57BL/6J	MGI:3577612
cx4	Irf2^tm1Mak/Irf2^tm1Mak Irf9^tm1Ttg/Irf9^tm1Ttg	involves: 129S2/SvPas * C57BL/6 * CBA	MGI:3630268

Allelic Composition	Irf9^tm1Ttg/Irf9^tm1Ttg
Genetic Background	B6.Cg-Irf9^tm1Ttg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf9^tm1Ttg mutation (2 available); any Irf9 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased interferon-alpha secretion ( J:97662 )

• CpG-A-induced production of interferon-alpha was abolished

skeleton

decreased bone mineral density ( J:84894 )

• mice exhibit a 40% decreased in bone volume in the trabecular bone compared to in wild-type mice

Allelic Composition	Irf9^tm1Ttg/Irf9^tm1Ttg
Genetic Background	either: (involves: C57BL/6 * CBA * ICR) or (involves: A/J * C57BL/6 * CBA)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf9^tm1Ttg mutation (2 available); any Irf9 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to viral infection ( J:77456 )

• antivirus responses induced by Ifn alpha and Ifn gamma were impaired

Allelic Composition	Irf3^tm1Ttg/Irf3^tm1Ttg Irf9^tm1Ttg/Irf9^tm1Ttg
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf3^tm1Ttg mutation (3 available); any Irf3 mutation (37 available)
Irf9^tm1Ttg mutation (2 available); any Irf9 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal cytokine secretion ( J:98127 )

• Newcastle disease virus infected MEFs had undetectable interferon-alpha/beta activity, indicating that mutant MEFs are incapable of responding to infection

Allelic Composition	Irf2^tm1Mak/Irf2^tm1Mak Irf9^tm1Ttg/Irf9^tm1Ttg
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf2^tm1Mak mutation (1 available); any Irf2 mutation (24 available)
Irf9^tm1Ttg mutation (2 available); any Irf9 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal skin condition ( J:66034 )

• no skin symptoms are observed up to 4 months of age compared to Irf2-null mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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