Analysis Tools
immune system
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• splenocyte cultures show increased sensitivity (impaired cell growth) to hypertonic stress
• 70% reduction of splenocytes in S phase
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• 30% reduction in thymus cellularity
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• reduction in numbers of peripheral T cells
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• 25% reduction in percentage of CD4+ cells in the spleen
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• 50% reduction in percentage of CD8+ cells in the spleen
• reduction in percentage of CD8+ cells in peripheral lymph nodes
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• 15% reduction in spleen cellularity
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• mutants develop impaired antigen-specific antibody and cytotoxic T cell responses
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• thymocyte cultures show increased sensitivity (impaired cell growth) to hypertonic stress
• T cells exhibit impaired growth under conditions of medium depletion compared to control T cells, however they do not show increased sensitivity to a reduction in pH or serum deprivation, suggesting that sensitivity is due to osmolarity
• T cells exhibit impaired growth in response to amino acid deprivation
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• mutants develop impaired cytotoxic T cell responses
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hematopoietic system
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• splenocyte cultures show increased sensitivity (impaired cell growth) to hypertonic stress
• 70% reduction of splenocytes in S phase
|
|
• 30% reduction in thymus cellularity
|
|
• reduction in numbers of peripheral T cells
|
|
• 25% reduction in percentage of CD4+ cells in the spleen
|
|
• 50% reduction in percentage of CD8+ cells in the spleen
• reduction in percentage of CD8+ cells in peripheral lymph nodes
|
|
• 15% reduction in spleen cellularity
|
|
• mutants develop impaired antigen-specific antibody and cytotoxic T cell responses
|
|
• thymocyte cultures show increased sensitivity (impaired cell growth) to hypertonic stress
• T cells exhibit impaired growth under conditions of medium depletion compared to control T cells, however they do not show increased sensitivity to a reduction in pH or serum deprivation, suggesting that sensitivity is due to osmolarity
• T cells exhibit impaired growth in response to amino acid deprivation
|
|
• mutants develop impaired cytotoxic T cell responses
|
cellular
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• thymocyte cultures show increased sensitivity (impaired cell growth) to hypertonic stress
• T cells exhibit impaired growth under conditions of medium depletion compared to control T cells, however they do not show increased sensitivity to a reduction in pH or serum deprivation, suggesting that sensitivity is due to osmolarity
• T cells exhibit impaired growth in response to amino acid deprivation
|
|
• splenocyte cultures show increased sensitivity (impaired cell growth) to hypertonic stress
• 70% reduction of splenocytes in S phase
|
endocrine/exocrine glands
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• 30% reduction in thymus cellularity
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