Phenotypes associated with this allele

• Allele Symbol: Tg(Ckmm-Ucp1)1Boud
• Allele Name: transgene insertion 1, Frederic Bouillaud
• Allele ID: MGI:2446436
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Ckmm-Ucp1)1Boud/Tg(Ckmm-Ucp1)1Boud	involves: C57BL/6J * DBA/2J	MGI:4366713
tg2	Tg(Ckmm-Ucp1)1Boud/0	involves: C57BL/6J * DBA/2J	MGI:2652171

Genotype
MGI:4366713

tg1

• Allelic Composition: Tg(Ckmm-Ucp1)1Boud/Tg(Ckmm-Ucp1)1Boud
• Genetic Background: involves: C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased percent body fat/body weight ( J:80053 )

• although mutants exhibit the average normal 15% body fat, they do not exhibit significant increases in percentage of body fat seen in 36% of the controls

behavior/neurological

polyphagia ( J:80053 )

• when food intake is corrected for body weight, mutants are hyperphagic compared to controls

cellular

abnormal cellular respiration ( J:80053 )

• muscle mitochondria have reduced ability to oxidize alpha-glycerophosphate

• the ratio between phosphocreatine and ATP at rest is decreased, indicating an increase in cytosolic ADP

growth/size/body

decreased body weight ( J:80053 )

• 30% reduction in body weight after 5 weeks of age

homeostasis/metabolism

abnormal blood homeostasis ( J:80053 )

• reduction in urea concentration in males

decreased circulating creatinine level ( J:80053 )

increased energy expenditure ( J:80053 )

muscle

abnormal skeletal muscle morphology ( J:80053 )

decreased gastrocnemius weight ( J:80053 )

decreased skeletal muscle fiber diameter ( J:80053 )

• reduction in the fiber cross-sectional area of fiber types IIa and IIx/IIb in plantaris muscles and gastronecmius muscles

abnormal skeletal muscle fiber type ratio ( J:80053 )

• gastrocnemius and plantaris muscles show a fast to slow shift in fiber types promoting mainly IIa and IIx fibers at the expense of fastest and glycolytic type IIb fibers

decreased skeletal muscle mass ( J:80053 )

• decrease in the relative mass for the total leg

decreased skeletal muscle weight ( J:80053 )

• weight of fast twitch skeletal muscles (plantaris and gastrocnemius) are lower than in controls, whereas weights of slow twitch skeletal and heart muscle are unchanged

limbs/digits/tail

decreased gastrocnemius weight ( J:80053 )

Genotype
MGI:2652171

tg2

• Allelic Composition: Tg(Ckmm-Ucp1)1Boud/0
• Genetic Background: involves: C57BL/6J * DBA/2J

behavior/neurological

polyphagia ( J:80053 )

• when food intake is corrected for body weight, mutants are hyperphagic compared to controls

growth/size/body

decreased body weight ( J:80053 )

• 30% reduction in body weight after 5 weeks of age

homeostasis/metabolism

abnormal blood homeostasis ( J:80053 )

• reduction in urea concentration in males

decreased circulating creatinine level ( J:80053 )

increased energy expenditure ( J:80053 )

abnormal enzyme/coenzyme activity ( J:80053 )

• activities of creatine kinase, adenylate kinase and lactate dehydrogenase are significantly decreased in gastrocnemius and plantaris muscle

muscle

abnormal skeletal muscle morphology ( J:80053 )

decreased gastrocnemius weight ( J:80053 )

decreased skeletal muscle fiber diameter ( J:80053 )

• reduction in the fiber cross-sectional area of fiber types IIa and IIx/IIb in plantaris muscles and gastronecmius muscles

abnormal skeletal muscle fiber type ratio ( J:80053 )

• gastrocnemius and plantaris muscles show a fast to slow shift in fiber types promoting mainly IIa and IIx fibers at the expense of fastest and glycolytic type IIb fibers

decreased skeletal muscle mass ( J:80053 )

• decrease in the relative mass for the total leg

decreased skeletal muscle weight ( J:80053 )

• weight of fast twitch skeletal muscles (plantaris and gastrocnemius) are lower than in controls, whereas weights of slow twitch skeletal and heart muscle are unchanged

adipose tissue

decreased percent body fat/body weight ( J:80053 )

• although mutants exhibit the average normal 15% body fat, they do not exhibit significant increases in percentage of body fat seen in 36% of the controls

cellular

abnormal cellular respiration ( J:80053 )

• muscle mitochondria have reduced ability to oxidize alpha-glycerophosphate

• the ratio between phosphocreatine and ATP at rest is decreased, indicating an increase in cytosolic ADP

limbs/digits/tail

decreased gastrocnemius weight ( J:80053 )